chb chromosome bows [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: chbprovided by FlyBase
Official Full Name: chromosome bowsprovided by FlyBase
Primary source: FLYBASE:FBgn0021760
Locus tag: Dmel_CG32435
See related: AllianceGenome:FB:FBgn0021760
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0686/07; anon-WO0104295; BcDNA:LD31673; CG32435; Chb; chb(v40); chb/mast/orbit; clasp; CLASP; dCLASP; DMAP160; Dmel\CG32435; mast; Mast; MAST; mast/orbit; Mast/Orbit; MAST/Orbit; MESR7; NEST:bs13a06; NEST:bs17d05; NEST:bs28g05; orb; orbit; Orbit; orbit/mast; orbit/MAST; Orbit/Mast; Orbit/MAST; v40
Summary: Enables GTP binding activity and microtubule binding activity. Involved in several processes, including germ cell development; hemocyte migration; and microtubule cytoskeleton organization. Located in several cellular components, including fusome; microtubule cytoskeleton; and spectrosome. Part of microtubule associated complex. Is expressed in several structures, including adult head; larval brain; motor neurons; ovary; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 78C1-78C2; 3-47 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (21172853..21183278)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (21165953..21176378)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Orbit/CLASP determines centriole length by antagonising Klp10A in Drosophila spermatocytes.
Title: Orbit/CLASP determines centriole length by antagonising Klp10A in Drosophila spermatocytes.
Findings suggest that Msps is a novel Rac effector that acts, in partnership with Orbit, to regionally regulate microtubule dynamics.
Title: TOG Proteins Are Spatially Regulated by Rac-GSK3β to Control Interphase Microtubule Dynamics.
Orbit plays an essential role as a connector between microtubules and the contractile ring in Drosophila male meiosis.
Title: Orbit/CLASP is required for myosin accumulation at the cleavage furrow in Drosophila male meiosis.
Orbit is involved in the proper orientation of spindles towards fusomes during synchronous mitosis of spermatogonial cysts.
Title: Orbit/CLASP is required for germline cyst formation through its developmental control of fusomes and ring canals in Drosophila males.
Data suggest a model in which CLASP and Msps converge in an antagonistic balance in the Abl signaling pathway.
Title: Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila.
Dynein and mast/orbit/CLASP have antagonistic roles in regulating kinetochore-microtubule plus-end dynamics.
Title: Dynein and mast/orbit/CLASP have antagonistic roles in regulating kinetochore-microtubule plus-end dynamics.
results suggest that Mast plays an essential role in reducing the dynamic behaviour of microtubules by specifically promoting the pause state
Title: The Drosophila CLASP homologue, Mast/Orbit regulates the dynamic behaviour of interphase microtubules by promoting the pause state.
is an essential component for microtubule subunit incorporation into fluxing K-fibres
Title: Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres.
MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity.
Title: MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity.
Orbit/Mast/CLASP localizes to interior rather than peripheral central spindle microtubules
Title: Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2211 (e-PCR)
- UniSTS:49370

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables tubulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cystoblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian fusome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in basal cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in contractile ring	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in germline ring canal	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule organizing center	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule plus-end	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polar microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in spectrosome	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chromosome bows

Names: CG32435-PA; CG32435-PB; CG32435-PC; MAST/Orbit; Orbit/MAST; Orbit/Mast/CLASP; chb-PA; chb-PB; chb-PC; clasp; mast; misexpression suppressor of ras 7; multiple asters; orbit; orbit/clasp

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

21172853..21183278

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168882.2 → NP_730596.1 chromosome bows, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730596.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V279, Q9NBD7, Q9NL57

Related

FBpp0088469, FBtr0089460

Conserved Domains (3) summary

pfam12348
Location:316 → 536

CLASP_N; CLASP N terminal

pfam13646
Location:129 → 210

HEAT_2; HEAT repeats

sd00044
Location:50 → 78

HEAT; HEAT repeat [structural motif]
NM_079912.4 → NP_524651.2 chromosome bows, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524651.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V279, Q9NBD7, Q9NL57

Related

FBpp0088470

Conserved Domains (3) summary

pfam12348
Location:316 → 536

CLASP_N; CLASP N terminal

pfam13646
Location:129 → 210

HEAT_2; HEAT repeats

sd00044
Location:50 → 78

HEAT; HEAT repeat [structural motif]
NM_168883.1 → NP_730597.1 chromosome bows, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730597.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V279, Q9NBD7, Q9NL57

Related

FBpp0088471, FBtr0089462

Conserved Domains (3) summary

pfam12348
Location:316 → 536

CLASP_N; CLASP N terminal

pfam13646
Location:129 → 210

HEAT_2; HEAT repeats

sd00044
Location:50 → 78

HEAT; HEAT repeat [structural motif]