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jim jim [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43924, updated on 4-Jan-2025

Summary

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Official Symbol
jimprovided by FlyBase
Official Full Name
jimprovided by FlyBase
Primary source
FLYBASE:FBgn0027339
Locus tag
Dmel_CG11352
See related
AllianceGenome:FB:FBgn0027339
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:SD14927; CG11352; Dmel\CG11352; Jim; ovfc.K; ovk; OVK
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dendrite morphogenesis. Is expressed in several structures, including follicle cell; ganglia; gut section; and pharyngeal muscle cell. Orthologous to several human genes including ZNF502 (zinc finger protein 502); ZNF678 (zinc finger protein 678); and ZNF679 (zinc finger protein 679). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See jim in Genome Data Viewer
Location:
80A2-80A4; 3-47 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22789233..22835194, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22782333..22828294, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45961 Neighboring gene Secretory Pathway Calcium atpase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45659 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential expression of the Drosophila zinc finger gene jim in the follicular epithelium. Doerflinger H, et al. Mech Dev, 1999 Aug. PMID 10446279
  2. The role of Imp and Syp RNA-binding proteins in precise neuronal elimination by apoptosis through the regulation of transcription factors. Guan W, et al. Elife, 2024 Oct 4. PMID 39364747, Free PMC Article
  3. The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance. Tang R, et al. Cell Rep, 2020 Jun 23. PMID 32579921
  4. Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases. Southall TD, et al. Physiol Genomics, 2006 Jun 16. PMID 16609144
  5. Age-Dependent Changes in Transcription Factor FOXO Targeting in Female Drosophila. Birnbaum A, et al. Front Genet, 2019. PMID 31134124, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
jim
Names
CG11352-PC
CG11352-PD
CG11352-PE
CG11352-PF
CG11352-PG
CG11352-PH
CG11352-PI
jim-PC
jim-PD
jim-PE
jim-PF
jim-PG
jim-PH
jim-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22789233..22835194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143699.4 → NP_651956.1  jim, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651956.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NN10, Q7KAH0
    Related
    FBpp0078231
    Conserved Domains (5) summary
    COG5048
    Location:355 → 666
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:359 → 379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:553 → 575
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:596 → 620
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:327 → 382
    zf-C2H2_8; C2H2-type zinc ribbon

  2. NM_001259959.2 → NP_001246888.1  jim, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246888.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFP1, Q6NN10
    Conserved Domains (5) summary
    COG5048
    Location:355 → 671
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:359 → 379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:557 → 579
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:600 → 624
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:327 → 382
    zf-C2H2_8; C2H2-type zinc ribbon

  3. NM_001275292.1 → NP_001262221.1  jim, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262221.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGG2, Q6NN10
    Conserved Domains (4) summary
    COG5048
    Location:355 → 666
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:359 → 379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:553 → 575
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:596 → 620
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001275294.1 → NP_001262223.1  jim, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262223.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PIL6, Q6NN10
    Conserved Domains (4) summary
    COG5048
    Location:355 → 638
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:527 → 547
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:525 → 547
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:568 → 592
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001275293.1 → NP_001262222.1  jim, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262222.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PG92, Q6NN10
    Conserved Domains (4) summary
    COG5048
    Location:355 → 640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:527 → 547
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:525 → 547
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:568 → 592
    zf-H2C2_2; Zinc-finger double domain

  6. NM_168964.5 → NP_730746.1  jim, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730746.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NN10, Q7KAH0
    Related
    FBpp0305414
    Conserved Domains (5) summary
    COG5048
    Location:355 → 666
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:359 → 379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:553 → 575
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:596 → 620
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:327 → 382
    zf-C2H2_8; C2H2-type zinc ribbon

  7. NM_001014601.1 → NP_001014601.1  jim, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014601.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NN10, Q7KAH0
    Conserved Domains (5) summary
    COG5048
    Location:355 → 666
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:359 → 379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:553 → 575
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:596 → 620
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:327 → 382
    zf-C2H2_8; C2H2-type zinc ribbon
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NFP1 M9NFP1
M9PG92 M9PG92
M9PGG2 M9PGG2
M9PIL6 M9PIL6
Q7KAH0 Q7KAH0
Q8IG96 Q8IG96

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