U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cl clot [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43938, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
clprovided by FlyBase
Official Full Name
clotprovided by FlyBase
Primary source
FLYBASE:FBgn0000318
Locus tag
Dmel_CG11024
See related
AllianceGenome:FB:FBgn0000318
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE06767; CG11024; Dmel\CG11024
Summary
Predicted to enable protein-disulfide reductase (NAD(P)H) activity. Involved in eye pigment biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including anterior endoderm anlage; embryonic proventriculus inner layer; gut section; mesoderm; and posterior endoderm. Orthologous to human TXNDC17 (thioredoxin domain containing 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
25E5-25E5; 2-17 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5520135..5521382)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5520135..5521382)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45287 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44793 Neighboring gene Vacuolar protein sorting 52 Neighboring gene Elongator complex protein 4 Neighboring gene Chromosome associated protein D3 Neighboring gene Cytochrome c oxidase copper chaperone COX11

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structure-based analysis of Clot as a thioredoxin-related protein of 14 kDa in Drosophila via experimental and computational approaches. Kim K. Biotechnol Appl Biochem, 2018 May. PMID 29080217
  2. Interaction between pteridine synthesis and riboflavin accumulation in Drosophila melanogaster. Nickla H. Can J Genet Cytol, 1972 Mar. PMID 4624271
  3. Enzymatic conversion of dihydroneopterin triphosphate to the pyrimidodiazepine intermediate involved in the biosynthesis of the drosopterins in Drosophila melanogaster. Wiederrecht GJ, et al. J Biol Chem, 1984 Feb 25. PMID 6421807
  4. Molecular cloning and analysis of the chromosomal region 26A of Drosophila melanogaster. Knipple DC, et al. Mol Gen Genet, 1991 Apr. PMID 1903503
  5. Electrophoretic variants of alpha-glycerophosphate dehydrogenase in Drosophila melanogaster. Grell EH. Science, 1967 Dec 8. PMID 6058005

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-disulfide reductase (NAD(P)H) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-disulfide reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-disulfide reductase (NAD(P)H) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in eye pigment biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
clot
Names
CG11024-PA
CG11024-PB
CG11024-PC
cl-PA
cl-PB
cl-PC
NP_001260098.1
NP_001260099.1
NP_608930.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5520135..5521382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273169.1 → NP_001260098.1  clot, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260098.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMQ9
    Conserved Domains (1) summary
    pfam06110
    Location:6 → 124
    DUF953; Eukaryotic protein of unknown function (DUF953)

  2. NM_001273170.1 → NP_001260099.1  clot, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260099.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMQ9
    Conserved Domains (1) summary
    pfam06110
    Location:6 → 124
    DUF953; Eukaryotic protein of unknown function (DUF953)

  3. NM_135086.4 → NP_608930.1  clot, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608930.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMQ9
    Related
    FBpp0078728
    Conserved Domains (1) summary
    pfam06110
    Location:6 → 124
    DUF953; Eukaryotic protein of unknown function (DUF953)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMQ9 Q9VMQ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools