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trio - trio

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including nervous system development; positive regulation of Rho protein signal transduction; and positive regulation of synaptic assembly at neuromuscular junction. Located in growth cone. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including central nervous system; epidermis; mushroom body; synaptic neuropil domain; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal dominant intellectual developmental disorder 44; cerebral atherosclerosis; cerebral infarction; and coronary artery disease. Orthologous to human KALRN (kalirin RhoGEF kinase) and TRIO (trio Rho guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Dec 2024]

Genes similar to trio

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Species Gene Architecture aa