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trio - trio

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including nervous system development; positive regulation of Rho protein signal transduction; and positive regulation of synaptic assembly at neuromuscular junction. Located in growth cone. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including epidermis; mushroom body; synaptic neuropil domain; synaptic neuropil subdomain; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal dominant intellectual developmental disorder 44; cerebral atherosclerosis; cerebral infarction; and coronary artery disease. Orthologous to human KALRN (kalirin RhoGEF kinase) and TRIO (trio Rho guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to trio

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Species Gene Architecture aa