Sdic1 Sperm-specific dynein intermediate chain 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sdic1provided by FlyBase
Official Full Name: Sperm-specific dynein intermediate chain 1provided by FlyBase
Primary source: FLYBASE:FBgn0067861
Locus tag: Dmel_CG9580
See related: AllianceGenome:FB:FBgn0067861
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9580; Dmel\CG9580; Sdic:CG9580
Summary: Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in microtubule-based movement. Located in sperm flagellum. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) and DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: 19C1-19C1; 1-64 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (20174217..20178638, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (20068250..20072671, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Understanding the Early Evolutionary Stages of a Tandem Drosophilamelanogaster-Specific Gene Family: A Structural and Functional Population Study.
Title: Understanding the Early Evolutionary Stages of a Tandem Drosophilamelanogaster-Specific Gene Family: A Structural and Functional Population Study.
The life history of the RT1C elements in the genome of D. melanogaster was used to determine the insertion chronology of the elements in the cluster and to date the duplication events that originated this cluster.
Title: The use of a non-LTR element to date the formation of the Sdic gene cluster.
Sdic protein becomes incorporated into the tail of the mature sperm and may function as an axonemal dynein intermediate chain
Title: Origin and evolution of a new gene expressed in the Drosophila sperm axoneme.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IEA Inferred from Electronic Annotation more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Sperm-specific dynein intermediate chain 1

Names: CG9580-PA; CG9580-PC; Sdic1-PA; Sdic1-PC; Sdic:CG9580

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

20174217..20178638 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079931.4 → NP_524670.2 Sperm-specific dynein intermediate chain 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524670.2

Status: REVIEWED

UniProtKB/TrEMBL

O96509, Q9W5W4

Related

FBpp0088559

Conserved Domains (5) summary

COG2319
Location:196 → 442

WD40; WD40 repeat [General function prediction only]

COG2811
Location:108 → 178

NtpH; Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]

pfam11540
Location:23 → 51

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

sd00039
Location:196 → 245

7WD40; WD40 repeat [structural motif]

cl02567
Location:196 → 445

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001258848.1 → NP_001245777.1 Sperm-specific dynein intermediate chain 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245777.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NE47, O96509

Conserved Domains (5) summary

COG2319
Location:199 → 440

WD40; WD40 repeat [General function prediction only]

COG2811
Location:111 → 181

NtpH; Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]

pfam11540
Location:23 → 51

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

sd00039
Location:200 → 245

7WD40; WD40 repeat [structural motif]

cl02567
Location:199 → 429

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...