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RNASE13 ribonuclease A family member 13 (inactive) [ Homo sapiens (human) ]

Gene ID: 440163, updated on 27-Nov-2024

Summary

Official Symbol
RNASE13provided by HGNC
Official Full Name
ribonuclease A family member 13 (inactive)provided by HGNC
Primary source
HGNC:HGNC:25285
See related
Ensembl:ENSG00000206150 AllianceGenome:HGNC:25285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAL1; HEL-S-86p
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See RNASE13 in Genome Data Viewer
Location:
14q11.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (21032818..21034807, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (15230221..15232210, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21500977..21502966, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21467511-21468710 Neighboring gene solute carrier family 39 member 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21487674-21488873 Neighboring gene NDRG family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5576 Neighboring gene microRNA 6717 Neighboring gene tubulin polymerization promoting protein family member 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:21507297-21507461 Neighboring gene uncharacterized LOC105370398 Neighboring gene ribonuclease A family member 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables RNA nuclease activity IKR
Inferred from Key Residues
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable inactive ribonuclease-like protein 13
Names
epididymis secretory sperm binding protein Li 86p
ribonuclease 13
ribonuclease A L1
ribonuclease, RNase A family, 13 (non-active)
ribonuclease-like protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012264.4NP_001012264.1  probable inactive ribonuclease-like protein 13 precursor

    See identical proteins and their annotated locations for NP_001012264.1

    Status: VALIDATED

    Source sequence(s)
    AL161668, AY665808, BC044831
    Consensus CDS
    CCDS32039.1
    UniProtKB/Swiss-Prot
    Q5GAN3
    UniProtKB/TrEMBL
    V9HW52
    Related
    ENSP00000372410.3, ENST00000382951.4
    Conserved Domains (1) summary
    cd00163
    Location:27142
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    21032818..21034807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    15230221..15232210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)