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slpr slipper [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44111, updated on 9-Dec-2024

Summary

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Official Symbol
slprprovided by FlyBase
Official Full Name
slipperprovided by FlyBase
Primary source
FLYBASE:FBgn0030018
Locus tag
Dmel_CG2272
See related
AllianceGenome:FB:FBgn0030018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2; Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr
Summary
Enables JUN kinase kinase kinase activity. Involved in several processes, including cellular response to ethanol; dorsal appendage formation; and imaginal disc morphogenesis. Located in cell cortex. Is expressed in adult head; adult thorax; and organism. Orthologous to several human genes including MAP3K11 (mitogen-activated protein kinase kinase kinase 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See slpr in Genome Data Viewer
Location:
7D17-7D17; 1-22 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8170229..8177185, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8064262..8071218, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45536 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 7a Neighboring gene stardust Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila. Clavier A, et al. Cell Cycle, 2016. PMID 26825229, Free PMC Article
  2. Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3. Sathyanarayana P, et al. Mol Cell, 2002 Dec. PMID 12504027
  3. Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila. Stronach B, et al. Genetics, 2014 Jun. PMID 24429281, Free PMC Article
  4. Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli. Zhuang ZH, et al. Cell Signal, 2006 Apr. PMID 16014325
  5. The adaptor protein Cindr regulates JNK activity to maintain epithelial sheet integrity. Yasin HWR, et al. Dev Biol, 2016 Feb 15. PMID 26772997

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rbf1-induced apoptosis activates a compensatory proliferation mechanism which also depends on Slipper and TRAF1, indicating that these two proteins seem to be key players of compensatory proliferation in Drosophila.
    Title: Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila.
  2. Slpr is dispensable for Eiger/TNF-induced cell death and innate immune response mediated by Tak1
    Title: Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila.
  3. PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.
    Title: The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model.
  4. a posttranslational modification on Slpr, at a conserved site among MAP3K mixed lineage kinase family members, which bolsters stress resistance with negligible effects on JNK-dependent developmental proces
    Title: Drosophila heat shock response requires the JNK pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif.
  5. The N-terminal half of Slpr is involved in regulating JNK signaling.
    Title: Regulation of mixed-lineage kinase activation in JNK-dependent morphogenesis.
  6. evidence that dMLK/slipper can be classified as a MAPKKK family member in the activation of the JNK pathway
    Title: Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling.
  7. activated by ceramide
    Title: Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3.
  8. SLPR overexpression can induce ectopic Jun-N-terminal kinase kinase signaling; SLPR protein is enriched at the epithelial cell cortex.
    Title: Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables JUN kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables JUN kinase kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure TAS
Traceable Author Statement
more info
 PubMed 
involved_in dorsal closure, elongation of leading edge cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc fusion, thorax closure IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in imaginal disc fusion, thorax closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived female genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived male genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vascular endothelial growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
slipper
Names
CG2272-PA
CG2272-PB
CG2272-PC
CG2272-PD
mixed lineage protein kinase 2
slpr-PA
slpr-PB
slpr-PC
slpr-PD
NP_001188558.1
NP_001188559.1
NP_001188560.1
NP_572458.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    8170229..8177185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201630.2 → NP_001188559.1  slipper, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188559.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MRK7, Q95UN8, Q95VF6, Q9W3I3
    UniProtKB/TrEMBL
    H1UUR7, M9MS26
    Conserved Domains (3) summary
    smart00219
    Location:129 → 386
    TyrKc; Tyrosine kinase, catalytic domain
    cd11876
    Location:47 → 104
    SH3_MLK; Src Homology 3 domain of Mixed Lineage Kinases
    cd14061
    Location:134 → 389
    STKc_MLK; Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases

  2. NM_001201631.2 → NP_001188560.1  slipper, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188560.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MRK7, Q95UN8, Q95VF6, Q9W3I3
    UniProtKB/TrEMBL
    H1UUR7, M9MS26
    Conserved Domains (3) summary
    smart00219
    Location:129 → 386
    TyrKc; Tyrosine kinase, catalytic domain
    cd11876
    Location:47 → 104
    SH3_MLK; Src Homology 3 domain of Mixed Lineage Kinases
    cd14061
    Location:134 → 389
    STKc_MLK; Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases

  3. NM_132230.4 → NP_572458.3  slipper, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572458.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MRK7, Q95UN8, Q95VF6, Q9W3I3
    UniProtKB/TrEMBL
    H1UUR7, M9MS26
    Conserved Domains (3) summary
    smart00219
    Location:129 → 386
    TyrKc; Tyrosine kinase, catalytic domain
    cd11876
    Location:47 → 104
    SH3_MLK; Src Homology 3 domain of Mixed Lineage Kinases
    cd14061
    Location:134 → 389
    STKc_MLK; Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases

  4. NM_001201629.2 → NP_001188558.1  slipper, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188558.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MRK7, Q95UN8, Q95VF6, Q9W3I3
    UniProtKB/TrEMBL
    H1UUR7, M9MSN2
    Conserved Domains (3) summary
    smart00219
    Location:129 → 386
    TyrKc; Tyrosine kinase, catalytic domain
    cd11876
    Location:47 → 104
    SH3_MLK; Src Homology 3 domain of Mixed Lineage Kinases
    cd14061
    Location:134 → 389
    STKc_MLK; Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MS26 M9MS26
M9MSN2 M9MSN2
Q95UN8.1 Q95UN8

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