U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

vih vihar [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44118, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
vihprovided by FlyBase
Official Full Name
viharprovided by FlyBase
Primary source
FLYBASE:FBgn0264848
Locus tag
Dmel_CG10682
See related
AllianceGenome:FB:FBgn0264848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1105/01; anon-WO0172774.54; anon-WO0172774.55; anon-WO0172774.56; CG10682; Dmel\CG10682; l(3)S110501; UbcH10
Summary
Enables ubiquitin conjugating enzyme activity. Involved in several processes, including anaphase-promoting complex-dependent catabolic process; exit from mitosis; and positive regulation of mitotic metaphase/anaphase transition. Located in nucleus. Part of ubiquitin conjugating enzyme complex. Colocalizes with spindle pole centrosome. Is expressed in organism. Orthologous to human UBE2C (ubiquitin conjugating enzyme E2 C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See vih in Genome Data Viewer
Location:
69C4-69C4; 3-38 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12504292..12505821)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12497392..12498921)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43868 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sticky Neighboring gene long non-coding RNA:CR45168 Neighboring gene trailer hitch

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2. Nagy O, et al. Cell Div, 2012 Mar 14. PMID 22417125, Free PMC Article
  2. The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis. Braun AL, et al. Open Biol, 2021 Jun. PMID 34186008, Free PMC Article
  3. Mitosis: a matter of getting rid of the right protein at the right time. Pines J. Trends Cell Biol, 2006 Jan. PMID 16337124
  4. The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation. Máthé E, et al. Curr Biol, 2004 Oct 5. PMID 15458643
  5. Identification of a physiological E2 module for the human anaphase-promoting complex. Williamson A, et al. Proc Natl Acad Sci U S A, 2009 Oct 27. PMID 19822757, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vihar E2 ubiquitin-conjugating enzyme contributes to the spatiotemporal control of Cyclin B degradation that first occurs at the spindle poles in mitosis.
    Title: The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaphase-promoting complex-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic metaphase/anaphase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with spindle pole centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin conjugating enzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
vihar
Names
CG10682-PA
lethal (3) S110501
vih-PA
NP_648582.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12504292..12505821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140325.3 → NP_648582.1  vihar [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648582.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTY6
    Related
    FBpp0075690
    Conserved Domains (2) summary
    COG5078
    Location:31 → 166
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:36 → 172
    UQ_con; Ubiquitin-conjugating enzyme
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTY6.1 Q9VTY6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous