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CG10939 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44155, updated on 9-Dec-2024

Summary

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Official Symbol
CG10939provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0010620
Locus tag
Dmel_CG10939
See related
AllianceGenome:FB:FBgn0010620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10939; l(2)06373; Sip1
Summary
Enables molecular adaptor activity. Involved in several processes, including epithelial structure maintenance; positive regulation of cell-cell adhesion; and regulation of renal system process. Is active in cytoplasmic side of apical plasma membrane. Is expressed in several structures, including adult head; anlage in statu nascendi; embryonic/larval midgut primordium; gut section; and head epidermis primordium. Used to study hypophosphatemic nephrolithiasis/osteoporosis 2. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human NHERF1 (NHERF family PDZ scaffold protein 1) and NHERF2 (NHERF family PDZ scaffold protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG10939 in Genome Data Viewer
Location:
54B6-54B7; 2-82 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17394593..17405171)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13282098..13292676)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Alanine-TGC 1-1 Neighboring gene transfer RNA:Alanine-TGC 2-1 Neighboring gene Cathelicidin-like antimicrobial protein Neighboring gene Vajk4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of cell proliferation and adhesion by means of a novel region of drosophila merlin interacting with Sip1. Abeysundara N, et al. Dev Dyn, 2014 Dec. PMID 25204795
  2. The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila. Yang Y, et al. Dev Biol, 2012 Jan 15. PMID 22133918
  3. Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity. Hughes SC, et al. J Cell Sci, 2010 Apr 1. PMID 20215404, Free PMC Article
  4. Targeted renal knockdown of Na(+)/H(+) exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila. Ghimire S, et al. Am J Physiol Renal Physiol, 2019 Oct 1. PMID 31364377, Free PMC Article
  5. Molecular cloning of the Drosophila melanogaster gene alpha5_dm encoding a 20S proteasome alpha-type subunit. Zaiss D, et al. Gene, 1997 Nov 12. PMID 9409776

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sip1 facilitates the activation of Merlin as a tumor suppressor protein.
    Title: Regulation of cell proliferation and adhesion by means of a novel region of drosophila merlin interacting with Sip1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial structure maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of renal system process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic side of apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG10939-PA
SRY interacting protein 1
sex-determining region Y protein-interacting protein-1
NP_524712.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17394593..17405171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079973.3 → NP_524712.1  uncharacterized protein Dmel_CG10939 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524712.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K5M6
    Related
    FBpp0086065
    Conserved Domains (1) summary
    cd00992
    Location:20 → 101
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K5M6 Q7K5M6

Gene LinkOut

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