bab2 bric a brac 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bab2provided by FlyBase
Official Full Name: bric a brac 2provided by FlyBase
Primary source: FLYBASE:FBgn0025525
Locus tag: Dmel_CG9102
See related: AllianceGenome:FB:FBgn0025525
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bab; BAB; bab-II; Bab2; BAB2; BTB-II; BtbII; CG13911; CG9102; Dmel\CG9102
Summary: Enables minor groove of adenine-thymine-rich DNA binding activity. Involved in female gonad morphogenesis; imaginal disc morphogenesis; and regulation of stem cell differentiation. Located in nucleus and polytene chromosome. Is expressed in several structures, including central nervous system; gut section; imaginal disc; tarsal segment; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 61F2-61F3; 3-0 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1140429..1177276, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1140429..1177276, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bab2 Functions as an Ecdysone-Responsive Transcriptional Repressor during Drosophila Development.
Title: Bab2 Functions as an Ecdysone-Responsive Transcriptional Repressor during Drosophila Development.
The Bric-a-Brac BTB/POZ transcription factors are necessary in niche cells for germline stem cells establishment and homeostasis through control of BMP/DPP signaling in the Drosophila melanogaster ovary.
Title: The Bric-à-Brac BTB/POZ transcription factors are necessary in niche cells for germline stem cells establishment and homeostasis through control of BMP/DPP signaling in the Drosophila melanogaster ovary.
Genetic variation at the bab locus affects bab expression and female abdominal pigmentation. Expression levels vary with temperature, participate in the pigmentation difference between the Dark and Pale lines.
Title: bric à brac (bab), a central player in the gene regulatory network that mediates thermal plasticity of pigmentation in Drosophila melanogaster.
In Drosophila melanogaster, dimorphic pigmentation is controlled by the dimorphic expression of the paralogous Bab1 and Bab2 transcription factors that repress pigmentation.
Title: The evolution of Bab paralog expression and abdominal pigmentation among Sophophora fruit fly species.
targeted loss of function of bric-a-brac 2 (bab2) affects morphogenesis without changing somatic gonad precursors cell number
Title: Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila.
Sequence variation at the bric a brac (bab) locus of Drosophila melanogaster, was examined.
Title: Contrasting patterns of sequence evolution at the functionally redundant bric à brac paralogs in Drosophila melanogaster.
The tissue distribution of Bab1 and Bab2 overlaps, with Bab1 being expressed in a subpattern of Bab2.
Title: The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1984 (e-PCR)
- UniSTS:56415

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables minor groove of adenine-thymine-rich DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in eye-antennal disc morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in female gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bric a brac 2

Names: BTB-protein-II; Bric-a-brac 2; CG9102-PA; CG9102-PB; bab2-PA; bab2-PB; bric a brac; bric a brac II; bric-a-brac; bric-a-brac-2; bric-a-brac2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1140429..1177276 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274313.1 → NP_001261242.1 bric a brac 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261242.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBH6

Conserved Domains (3) summary

smart00225
Location:224 → 309

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:213 → 309

BTB; BTB/POZ domain

pfam05225
Location:644 → 689

HTH_psq; helix-turn-helix, Psq domain
NM_079155.3 → NP_523879.2 bric a brac 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523879.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24001, Q7YU69, Q9U1H3, Q9W0K4

Related

FBpp0072535

Conserved Domains (3) summary

smart00225
Location:224 → 309

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:213 → 309

BTB; BTB/POZ domain

pfam05225
Location:645 → 690

HTH_psq; helix-turn-helix, Psq domain