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Enables Wnt receptor activity; Wnt-protein binding activity; and coreceptor activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; long-term memory; and regionalization. Located in plasma membrane. Part of Wnt signalosome. Colocalizes with early endosome and late endosome. Is expressed in several structures, including embryonic dorsal epidermis; embryonic ventral epidermis; embryonic/larval neuromuscular junction; foregut primordium; and gut section. Human ortholog(s) of this gene implicated in several diseases, including bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; polycystic liver disease (multiple); and tooth agenesis. Orthologous to human LRP5 (LDL receptor related protein 5) and LRP6 (LDL receptor related protein 6). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa