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pie pineapple eye [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44315, updated on 4-Jan-2025

Summary

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Official Symbol
pieprovided by FlyBase
Official Full Name
pineapple eyeprovided by FlyBase
Primary source
FLYBASE:FBgn0005683
Locus tag
Dmel_CG5354
See related
AllianceGenome:FB:FBgn0005683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5354; Dmel\CG5354; l(2)31Ek; l(2)54; mat(2)ea-E; mat(2)earlyQM47; mat(2)QM47; Pie
Summary
Involved in several processes, including germ-line stem cell division; intestinal stem cell homeostasis; and somatic stem cell population maintenance. Predicted to be active in nucleus. Is expressed in organism. Orthologous to several human genes including PHF7 (PHD finger protein 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See pie in Genome Data Viewer
Location:
31E1-31E1; 2-42 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10420625..10422780, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10420625..10422780, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein at 31E Neighboring gene Replication factor C subunit 3 Neighboring gene WD repeat and FYVE domain containing 2 Neighboring gene Small ribonucleoprotein particle protein SmB

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss-of-Function Screen Reveals Novel Regulators Required for Drosophila Germline Stem Cell Self-Renewal. Xing Y, et al. G3 (Bethesda), 2012 Mar. PMID 22413088, Free PMC Article
  2. Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis. Wang XR, et al. Proc Biol Sci, 2017 May 31. PMID 28539513, Free PMC Article
  3. Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila. Mlodzik M, et al. Genes Dev, 1990 Nov. PMID 2125959
  4. Local Cell Death Changes the Orientation of Cell Division in the Developing Drosophila Wing Imaginal Disc Without Using Fat or Dachsous as Orienting Signals. Kale A, et al. PLoS One, 2016. PMID 28030539, Free PMC Article
  5. The pineapple eye gene is required for survival of Drosophila imaginal disc cells. Shi W, et al. Genetics, 2003 Dec. PMID 14704172, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pineapple eye
Names
CG5354-PA
CG5354-PB
lethal(2)54
maternal effect early arrest E
pie-PA
pie-PB
rumpled

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10420625..10422780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273419.1 → NP_001260348.1  pineapple eye, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260348.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NGN6, Q9VKW2
    Conserved Domains (2) summary
    pfam17061
    Location:318 → 491
    PARM; PARM
    cl22851
    Location:9 → 117
    PHD_SF; PHD finger superfamily

  2. NM_080001.4 → NP_524740.2  pineapple eye, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524740.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NGN6, Q9VKW2
    Related
    FBpp0079636
    Conserved Domains (2) summary
    pfam17061
    Location:318 → 491
    PARM; PARM
    cl22851
    Location:9 → 117
    PHD_SF; PHD finger superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKW2.1 Q9VKW2

Gene LinkOut

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