HDAC3 Histone deacetylase 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: HDAC3provided by FlyBase
Official Full Name: Histone deacetylase 3provided by FlyBase
Primary source: FLYBASE:FBgn0025825
Locus tag: Dmel_CG2128
See related: AllianceGenome:FB:FBgn0025825
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2128; dHDAC3; DHDAC3; Dmel\CG2128; dmHDA402; DmHDAC3; Dromel_CG2128_FBtr0078767_hdac3_mORF; HDAC; Hdac 3; hdac3; Hdac3
Summary: Enables histone deacetylase activity and protein domain specific binding activity. Involved in several processes, including cell dedifferentiation; negative regulation of neuroblast proliferation; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including larval brain; larval central nervous system; ovariole; presumptive embryonic/larval central nervous system; and wing disc. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 83A4-83A4; 3-47.5 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5472810..5474600, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1298532..1300322, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Separation of transcriptional repressor and activator functions in Drosophila HDAC3.
Title: Separation of transcriptional repressor and activator functions in Drosophila HDAC3.
Deacetylase-dependent and -independent role of HDAC3 in cardiomyopathy.
Title: Deacetylase-dependent and -independent role of HDAC3 in cardiomyopathy.
Brm-HDAC3-Erm repressor complex suppresses dedifferentiation of intermediate neural progenitors back into type II neuroblasts.
Title: The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages.
Hdac3 served as an important regulator of the PI3K pathway and revealed a novel link between histone acetylation and growth control.
Title: Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth of Drosophila organs through the acetylation of histone H4 at lysine 16.
Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
Title: Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.
Mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid.
Title: Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis.
Histone deacetylation is a repression mechanism in early Drosophila development.
Title: Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation.
) DHDAC1 and -3 have distinct functions in the control of gene expression
Title: Dissecting the biological functions of Drosophila histone deacetylases by RNA interference and transcriptional profiling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell dedifferentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed