U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Apold1 apolipoprotein L domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 444983, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Apold1provided by RGD
Official Full Name
apolipoprotein L domain containing 1provided by RGD
Primary source
RGD:1303123
See related
EnsemblRapid:ENSRNOG00000007830 AllianceGenome:RGD:1303123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Verge
Summary
Predicted to enable lipid binding activity. Involved in several processes, including endothelial cell activation; regulation of endothelial cell differentiation; and response to hypoxia. Predicted to be located in Weibel-Palade body and cell-cell junction. Orthologous to human APOLD1 (apolipoprotein L domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Apold1 in Genome Data Viewer
Location:
4q43
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169499728..169557075)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (167768437..167825706)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168752142..168755024)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350781 Neighboring gene G protein-coupled receptor 19 Neighboring gene cyclin-dependent kinase inhibitor 1B Neighboring gene proteasome maturation protein pseudogene Neighboring gene DEAD-box helicase 47 Neighboring gene G protein-coupled receptor, class C, group 5, member A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Verge: a novel vascular early response gene. Regard JB, et al. J Neurosci, 2004 Apr 21. PMID 15102925, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in autophagosome-dependent secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagosome-dependent secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome-dependent secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endothelial cell activation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of endothelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of endothelial cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of membrane permeability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane permeability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane permeability ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Weibel-Palade body IEA
Inferred from Electronic Annotation
more info
  
located_in Weibel-Palade body ISO
Inferred from Sequence Orthology
more info
  
located_in Weibel-Palade body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
apolipoprotein L domain-containing protein 1
Names
vascular early response gene protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003403.2 → NP_001003403.1  apolipoprotein L domain-containing protein 1

    See identical proteins and their annotated locations for NP_001003403.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q6B959
    UniProtKB/TrEMBL
    A6IME9
    Related
    ENSRNOP00000010289.4, ENSRNOT00000010289.6
    Conserved Domains (1) summary
    pfam05461
    Location:69 → 103
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    169499728..169557075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108001.2 → XP_038963929.1  apolipoprotein L domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G5B0
    Conserved Domains (1) summary
    pfam05461
    Location:74 → 108
    ApoL; Apolipoprotein L

  2. XM_039108003.2 → XP_038963931.1  apolipoprotein L domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G5B0
    Conserved Domains (1) summary
    pfam05461
    Location:74 → 108
    ApoL; Apolipoprotein L

  3. XM_039108004.2 → XP_038963932.1  apolipoprotein L domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G5B0
    Conserved Domains (1) summary
    pfam05461
    Location:74 → 108
    ApoL; Apolipoprotein L

  4. XM_039108005.2 → XP_038963933.1  apolipoprotein L domain-containing protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q6B959
    UniProtKB/TrEMBL
    A6IME9
    Conserved Domains (1) summary
    pfam05461
    Location:69 → 103
    ApoL; Apolipoprotein L

  5. XM_063286435.1 → XP_063142505.1  apolipoprotein L domain-containing protein 1 isoform X2

    Related
    ENSRNOP00000110723.1, ENSRNOT00000158892.1

  6. XM_063286434.1 → XP_063142504.1  apolipoprotein L domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G5B0
    Related
    ENSRNOP00000079429.1, ENSRNOT00000102557.2

  7. XM_039108006.2 → XP_038963934.1  apolipoprotein L domain-containing protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q6B959
    UniProtKB/TrEMBL
    A6IME9
    Related
    ENSRNOP00000109929.1, ENSRNOT00000130334.1
    Conserved Domains (1) summary
    pfam05461
    Location:69 → 103
    ApoL; Apolipoprotein L

RNA

  1. XR_005503274.2 RNA Sequence

  2. XR_005503268.2 RNA Sequence

  3. XR_010065683.1 RNA Sequence

  4. XR_010065682.1 RNA Sequence

  5. XR_005503271.2 RNA Sequence

  6. XR_005503270.2 RNA Sequence

  7. XR_005503269.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6B959.1 GenPept UniProtKB/Swiss-Prot:Q6B959

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools