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wech wech [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44653, updated on 9-Dec-2024

Summary

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Official Symbol
wechprovided by FlyBase
Official Full Name
wechprovided by FlyBase
Primary source
FLYBASE:FBgn0259745
Locus tag
Dmel_CG42396
See related
AllianceGenome:FB:FBgn0259745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1624; CG42396; Dmel\CG42396; dpld; Dpld; lin-41; Wech
Summary
Enables protein-macromolecule adaptor activity. Involved in instar larval development; muscle attachment; and regulation of cell-cell adhesion mediated by integrin. Located in muscle tendon junction. Is expressed in several structures, including CNS glial cell; epithelial cell; ganglia; head epidermis primordium; and sensory neurons. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human TRIM71 (tripartite motif containing 71). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See wech in Genome Data Viewer
Location:
43C5-43C5; 2-56 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7478853..7489823, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3366358..3377328, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Aldehyde dehydrogenase type III Neighboring gene p47 Neighboring gene antisense RNA:CR43723 Neighboring gene Corepressor of Pangolin Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A mis-expression study of factors affecting Drosophila PNS cell identity. O'Farrell F, et al. Biochem Biophys Res Commun, 2008 Jun 13. PMID 18420029
  2. Regulation of hemocytes in Drosophila requires dappled cytochrome b5. Kleinhesselink K, et al. Biochem Genet, 2011 Jun. PMID 21279680, Free PMC Article
  3. Genetic mapping of the p47 (L.3.2) mutation in Drosophilamelanogaster. Cordes CN, et al. MicroPubl Biol, 2023. PMID 37799208, Free PMC Article
  4. Temporal control of bidirectional lipid-droplet motion in Drosophila depends on the ratio of kinesin-1 and its co-factor Halo. Arora GK, et al. J Cell Sci, 2016 Apr 1. PMID 26906417, Free PMC Article
  5. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Pasquinelli AE, et al. Nature, 2000 Nov 2. PMID 11081512

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show taht dpld seems to be miRNA regulated, suggesting that miRNAs represent an ancient mechanism of LIN-41 regulation.
    Title: Regulation of the Drosophila lin-41 homologue dappled by let-7 reveals conservation of a regulatory mechanism within the LIN-41 subclade.
  2. String and dappled were identified as being important for the proper formation of adult external sensory (ES) organs.
    Title: A mis-expression study of factors affecting Drosophila PNS cell identity.
  3. Data suggest that Wech proteins are crucial and evolutionarily conserved regulators of the integrin-cytoskeleton link.
    Title: The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in instar larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell-cell adhesion mediated by integrin IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in muscle tendon junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
wech
Names
CG42396-PA
CG42396-PB
CG42396-PC
CG42396-PD
CG42396-PE
dappled
wech-PA
wech-PB
wech-PC
wech-PD
wech-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7478853..7489823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165534.3 → NP_724568.1  wech, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724568.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4IJ45, B7YZS8, Q0E9G5, Q95SY8, Q9V4M2
    Related
    FBpp0289359
    Conserved Domains (5) summary
    COG3391
    Location:527 → 740
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00021
    Location:187 → 224
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd14954
    Location:528 → 810
    NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
    sd00039
    Location:603 → 640
    7WD40; WD40 repeat [structural motif]
    cl23765
    Location:232 → 343
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. NM_001144142.3 → NP_001137614.1  wech, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137614.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4IJ45, B7YZS8, Q0E9G5, Q95SY8, Q9V4M2
    Conserved Domains (5) summary
    COG3391
    Location:527 → 740
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00021
    Location:187 → 224
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd14954
    Location:528 → 810
    NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
    sd00039
    Location:603 → 640
    7WD40; WD40 repeat [structural motif]
    cl23765
    Location:232 → 343
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  3. NM_080033.4 → NP_524772.2  wech, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524772.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4IJ45, B7YZS8, Q0E9G5, Q95SY8, Q9V4M2
    Related
    FBpp0289357
    Conserved Domains (5) summary
    COG3391
    Location:527 → 740
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00021
    Location:187 → 224
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd14954
    Location:528 → 810
    NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
    sd00039
    Location:603 → 640
    7WD40; WD40 repeat [structural motif]
    cl23765
    Location:232 → 343
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  4. NM_001144143.2 → NP_001137615.1  wech, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137615.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4IJ45, B7YZS8, Q0E9G5, Q95SY8, Q9V4M2
    Conserved Domains (5) summary
    COG3391
    Location:527 → 740
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00021
    Location:187 → 224
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd14954
    Location:528 → 810
    NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
    sd00039
    Location:603 → 640
    7WD40; WD40 repeat [structural motif]
    cl23765
    Location:232 → 343
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  5. NM_165533.3 → NP_724567.1  wech, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724567.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4IJ45, B7YZS8, Q0E9G5, Q95SY8, Q9V4M2
    Related
    FBpp0289358
    Conserved Domains (5) summary
    COG3391
    Location:527 → 740
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00021
    Location:187 → 224
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd14954
    Location:528 → 810
    NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
    sd00039
    Location:603 → 640
    7WD40; WD40 repeat [structural motif]
    cl23765
    Location:232 → 343
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V4M2.2 Q9V4M2

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