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coasy CoA synthase [ Danio rerio (zebrafish) ]

Gene ID: 447838, updated on 4-Jan-2025

Summary

Official Symbol
coasyprovided by ZNC
Official Full Name
CoA synthaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040912-137
See related
Ensembl:ENSDARG00000042747 AllianceGenome:ZFIN:ZDB-GENE-040912-137
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92337
Summary
Predicted to enable dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to act upstream of or within biosynthetic process. Is expressed in liver; muscle; nervous system; and somite. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia type 12. Orthologous to human COASY (Coenzyme A synthase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See coasy in Genome Data Viewer
Location:
chromosome: 24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (36275664..36301072, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (36387592..36413000, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene RIO kinase 3 (yeast) Neighboring gene si:ch211-40k21.5 Neighboring gene N-acetylglucosaminidase, alpha Neighboring gene pseudouridylate synthase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding  
enables catalytic activity  
enables dephospho-CoA kinase activity  
enables dephospho-CoA kinase activity  
enables nucleotide binding  
enables pantetheine-phosphate adenylyltransferase activity  

General protein information

Preferred Names
bifunctional coenzyme A synthase
Names
Coenzyme A synthase
NP_001004577.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004577.1 → NP_001004577.1  bifunctional coenzyme A synthase precursor

    See identical proteins and their annotated locations for NP_001004577.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081650
    UniProtKB/TrEMBL
    A0A8M1N265, Q66HW0
    Related
    ENSDARP00000062735.5, ENSDART00000062736.6
    Conserved Domains (3) summary
    cd02164
    Location:182 → 323
    PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
    COG0237
    Location:346 → 544
    CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
    cd02022
    Location:348 → 527
    DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    36275664..36301072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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