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tant tantalus [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44785, updated on 9-Dec-2024

Summary

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Official Symbol
tantprovided by FlyBase
Official Full Name
tantalusprovided by FlyBase
Primary source
FLYBASE:FBgn0028980
Locus tag
Dmel_CG6586
See related
AllianceGenome:FB:FBgn0028980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6586; Dmel\CG6586; tan; Tan
Summary
Involved in sensory organ development. Located in cytoplasm and nucleus. Is expressed in several structures, including dorsal pharyngeal muscle primordium; eye disc morphogenetic furrow; larval muscle cell; larval muscle system; and somatic mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See tant in Genome Data Viewer
Location:
65A4-65A4; 3-16 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6055136..6057002)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6048236..6050102)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Jonah 65Aii Neighboring gene Jonah 65Ai Neighboring gene long non-coding RNA:CR45441 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Little effect of the tan locus on pigmentation in female hybrids between Drosophila santomea and D. melanogaster. Matute DR, et al. Cell, 2009 Dec 11. PMID 20005810, Free PMC Article
  2. A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system. Romero-Calderón R, et al. PLoS Genet, 2008 Nov. PMID 18989452, Free PMC Article
  3. The functional organisation of glia in the adult brain of Drosophila and other insects. Edwards TN, et al. Prog Neurobiol, 2010 Apr. PMID 20109517, Free PMC Article
  4. Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila. Shao L, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 22049342, Free PMC Article
  5. Pigmentation and behavior: potential association through pleiotropic genes in Drosophila. Takahashi A. Genes Genet Syst, 2013. PMID 24025245

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In contrast to NBAD-synthase, Tan is expressed constitutively in epidermis and does not respond directly to microbial challenge. The study shows the novel localization of tan in embryo central neural system and in different regions of adult brain.
    Title: Constitutive expression and enzymatic activity of Tan protein in brain and epidermis of Ceratitis capitata and of Drosophila melanogaster wild-type and tan mutants.
  2. Hybridization tests using D. melanogaster deficiencies that include tan show no evidence that this locus is involved in the lighter pigmentation of D. santomea females; rather, the pigmentation difference appears to involve at least 4 other loci.
    Title: Little effect of the tan locus on pigmentation in female hybrids between Drosophila santomea and D. melanogaster.
  3. Tan expression is confined to the photoreceptor cells R1-R8.
    Title: Drosophila photoreceptors express cysteine peptidase tan.
  4. The previously observed ability of TAN to move between the cytoplasm and nucleus, and to associate with DNA, provides a potential mechanism for TAN to respond to N signalling.
    Title: tantalus, a potential link between Notch signalling and chromatin-remodelling complexes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in sensory organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tantalus
Names
CG6586-PA
CG6586-PB
tant-PA
tant-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6055136..6057002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274531.1 → NP_001261460.1  tantalus, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261460.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T0D4, Q9NHW6, Q9VRT0
    UniProtKB/TrEMBL
    M9PEG8
    Conserved Domains (1) summary
    pfam15386
    Location:121 → 174
    Tantalus; Drosophila Tantalus-like

  2. NM_080043.3 → NP_524782.2  tantalus, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524782.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T0D4, Q9NHW6, Q9VRT0
    UniProtKB/TrEMBL
    M9PEG8
    Related
    FBpp0076751
    Conserved Domains (1) summary
    pfam15386
    Location:121 → 174
    Tantalus; Drosophila Tantalus-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEG8 M9PEG8
Q8T0D4.1 Q8T0D4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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