U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

vac14 vac14 homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

Gene ID: 447912, updated on 4-Jan-2025

Summary

Official Symbol
vac14provided by ZNC
Official Full Name
vac14 homolog (S. cerevisiae)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040912-82
See related
Ensembl:ENSDARG00000014303 AllianceGenome:ZFIN:ZDB-GENE-040912-82
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb68e05; wu:fb68e05; zgc:100945
Summary
Predicted to be involved in phosphatidylinositol biosynthetic process. Predicted to be located in endoplasmic reticulum; endosome; and membrane. Predicted to be part of PAS complex. Predicted to be active in endosome membrane. Human ortholog(s) of this gene implicated in striatonigral degeneration. Orthologous to human VAC14 (VAC14 component of PIKFYVE complex). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See vac14 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (17590095..17611306)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (17493647..17514906)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 15a Neighboring gene zona pellucida glycoprotein d Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene transfer RNA aspartic acid (anticodon GUC)

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in phosphatidylinositol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphatidylinositol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of PAS complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of PAS complex IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004650.1NP_001004650.1  protein VAC14 homolog

    See identical proteins and their annotated locations for NP_001004650.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078425
    UniProtKB/Swiss-Prot
    Q66L58
    Related
    ENSDARP00000003288.6, ENSDART00000009767.8
    Conserved Domains (3) summary
    pfam11916
    Location:533707
    Vac14_Fig4_bd; Vacuolar protein 14 C-terminal Fig4p binding
    pfam12755
    Location:67163
    Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
    sd00044
    Location:94122
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    17590095..17611306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009297900.4XP_009296175.1  protein VAC14 homolog isoform X1

    UniProtKB/TrEMBL
    A0A0R4ITZ2, A0A8M3AWH2
    Related
    ENSDARP00000138390.1, ENSDART00000167750.2
    Conserved Domains (3) summary
    pfam11916
    Location:544718
    Vac14_Fig4_bd; Vacuolar protein 14 C-terminal Fig4p binding
    pfam12755
    Location:67163
    Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
    sd00044
    Location:94122
    HEAT; HEAT repeat [structural motif]