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bsk basket [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44801, updated on 4-Jan-2025

Summary

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Official Symbol
bskprovided by FlyBase
Official Full Name
basketprovided by FlyBase
Primary source
FLYBASE:FBgn0000229
Locus tag
Dmel_CG5680
See related
AllianceGenome:FB:FBgn0000229
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Basket; Bsk; BSK; bsk/JNK; CG5680; D-JNK; D-junk; DBSK/JNK; dJnk; dJNK; DJNK; DJNK/bsk; Dmel\CG5680; DmJNK; dNJNK; Jak; JAK; jnk; Jnk; JNK; jnk (bsk); JNK/SAPK; Junk; p-JNK; P-JNK; pJNK; SAPK/JNK; SAPKa
Summary
Enables JUN kinase activity. Involved in several processes, including axonogenesis; defense response to other organism; and morphogenesis of an epithelium. Located in axon; dendrite; and nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; epithelial furrow; head epidermis primordium; imaginal disc; and presumptive embryonic/larval system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; chronic mucocutaneous candidiasis; intestinal benign neoplasm (multiple); pancreatic adenocarcinoma; and type 2 diabetes mellitus. Orthologous to several human genes including MAPK10 (mitogen-activated protein kinase 10) and MAPK8 (mitogen-activated protein kinase 8). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See bsk in Genome Data Viewer
Location:
31B1-31B1; 2-40 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10247502..10250501, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10247502..10250501, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene maternal expression at 31B Neighboring gene antisense RNA:CR44995 Neighboring gene chico Neighboring gene uncharacterized protein Neighboring gene Ror Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of melatonin on Aβ42 induced changes in the mitochondrial function related to Alzheimer's disease in Drosophila melanogaster. Khatoon R, et al. Neurosci Lett, 2019 Oct 15. PMID 31325578
  2. Regulation and function of the JNK subgroup of MAP kinases. Minden A, et al. Biochim Biophys Acta, 1997 Oct 24. PMID 9395283
  3. The crystal structure of JNK from Drosophila melanogaster reveals an evolutionarily conserved topology with that of mammalian JNK proteins. Chimnaronk S, et al. BMC Struct Biol, 2015 Sep 16. PMID 26377800, Free PMC Article
  4. Identification of key cytosolic kinases containing evolutionarily conserved kinase tyrosine-based inhibitory motifs (KTIMs). Abu-Dayyeh I, et al. Dev Comp Immunol, 2010 May. PMID 20043942
  5. Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila. Takahama K, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22197814

See all (1181) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gp93 inhibits unfolded protein response-mediated c-Jun N-terminal kinase activation and cell invasion.
    Title: Gp93 inhibits unfolded protein response-mediated c-Jun N-terminal kinase activation and cell invasion.
  2. N-Acetyltransferase 9 ameliorates Abeta42-mediated neurodegeneration in the Drosophila eye.
    Title: N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye.
  3. c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD.
    Title: c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD.
  4. Rab11 negatively regulates wingless preventing JNK-mediated apoptosis in Drosophila epithelium during embryonic dorsal closure.
    Title: Rab11 negatively regulates wingless preventing JNK-mediated apoptosis in Drosophila epithelium during embryonic dorsal closure.
  5. Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells.
    Title: Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells.
  6. Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways.
    Title: Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways.
  7. JNK Signaling in Drosophila Aging and Longevity.
    Title: JNK Signaling in Drosophila Aging and Longevity.
  8. Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth.
    Title: Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth.
  9. ZnT7 RNAi favors Raf(GOF)scrib(-/-)-induced tumor growth and invasion in Drosophila through JNK signaling pathway.
    Title: ZnT7 RNAi favors Raf(GOF)scrib(-/-)-induced tumor growth and invasion in Drosophila through JNK signaling pathway.
  10. Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila.
    Title: Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables JUN kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antibacterial humoral response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to arsenic-containing substance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to cadmium ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chorion micropyle formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in collateral sprouting of injured axon IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of digestive tract left/right asymmetry IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure, spreading of leading edge cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic anterior midgut (ectodermal) morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc fusion, thorax closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived male genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term memory IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in melanization defense response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in melanization defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of border follicle cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cellular response to phosphate starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in wound healing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
basket
Names
CG5680-PB
CG5680-PE
CG5680-PF
JNK
JUN kinase
Jun N-terminal kinase
Jun NH2-terminal kinase
Jun-N terminal kinase
Jun-N-terminal kinase
Jun-kinase
bsk-PB
bsk-PE
bsk-PF
c-Jun N-terminal kinase
c-Jun aminoterminal kinase
c-Jun-N-terminal kinase
pJNK
NP_001162930.1
NP_001162932.1
NP_723541.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10247502..10250501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164900.3 → NP_723541.1  basket, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723541.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01366, P92208, Q94542
    UniProtKB/TrEMBL
    E1JHD6
    Related
    FBpp0079676
    Conserved Domains (1) summary
    cd07850
    Location:23 → 359
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. NM_001169459.1 → NP_001162930.1  basket, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162930.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01366, P92208, Q94542
    UniProtKB/TrEMBL
    E1JHD6
    Conserved Domains (1) summary
    cd07850
    Location:23 → 359
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  3. NM_001169461.3 → NP_001162932.1  basket, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162932.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01366, P92208, Q94542
    UniProtKB/TrEMBL
    E1JHD6
    Conserved Domains (1) summary
    cd07850
    Location:23 → 359
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JHD6 E1JHD6
P92208.1 P92208
Q8IGX1 Q8IGX1

Gene LinkOut

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