sdt stardust [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sdtprovided by FlyBase
Official Full Name: stardustprovided by FlyBase
Primary source: FLYBASE:FBgn0261873
Locus tag: Dmel_CG32717
See related: AllianceGenome:FB:FBgn0261873
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:fe2E6; BP1063; CG12657; CG12658; CG15339; CG15340; CG15341; CG15342; CG1617; CG32717; cGUK1; cMAGUK1; Dmel\CG32717; l(1)7Ef; pal1; Pals; Pals1; PALS1; Sdt; SDT; std; Std
Summary: Predicted to enable guanylate kinase activity. Involved in several processes, including apical protein localization; positive regulation of ubiquitin-dependent endocytosis; and zonula adherens assembly. Located in apical cortex; apical plasma membrane; and apicolateral plasma membrane. Part of subapical complex. Is expressed in several structures, including cuboidal/columnar epithelium; dorsal epidermis primordium; embryonic head epidermis; head; and head epidermis primordium. Used to study kidney disease. Orthologous to human PALS1 (protein associated with LIN7 1, MAGUK p55 family member). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 7D17-7D22; 1-22 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8178549..8240474)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8072582..8134507)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The E3 ubiquitin ligase Neuralized promotes the endocytosis of Crumbs via the NBM-containing isoforms of Stardust.
Title: Neuralized regulates Crumbs endocytosis and epithelium morphogenesis via specific Stardust isoforms.
The adaptor protein 2 (AP-2) complex binds to a motif in the cytoplasmic tail of Crumbs that overlaps with the binding site of Stardust, a protein known to stabilize Crumbs on the surface.
Title: AP-2-complex-mediated endocytosis of Drosophila Crumbs regulates polarity by antagonizing Stardust.
Crumbs localisation in the principal cells of the hindgut depends on Stardust. In contrast, localisation of Crumbs in the boundary cells does not require Stardust and is independent of its PDZ domain- and FERM-domain binding motifs.
Title: Apical localisation of crumbs in the boundary cells of the Drosophila hindgut is independent of its canonical interaction partner stardust.
The first PDZ domain of Patj associated with the Stardust-binding domain are sufficient to fully rescue both Drosophila viability and Crumbs localisation.
Title: Tissue-specific function of Patj in regulating the Crumbs complex and epithelial polarity.
Data show that Sdt-H (formerly called Sdt-B2) and Sdt-D, which differ in their N terminus, are expressed in adult photoreceptors.
Title: Antagonistic functions of two stardust isoforms in Drosophila photoreceptor cells.
Crb-Sdt complex is differentially regulated in pupal and adult photoreceptors. In pupals, only the PDZ domain of Sdt is required for apical targeting. In adult photoreceptors, targeting of Sdt to the apical membrane depends on domain structure
Title: Multiple domains of Stardust differentially mediate localisation of the Crumbs-Stardust complex during photoreceptor development in Drosophila.
Dynein regulates epithelial polarity and the apical localization of sdt mRNA.
Title: Dynein regulates epithelial polarity and the apical localization of stardust A mRNA.
All stardust proteins expressed in the retina contain the PSD95, Discs Large, ZO-1 (PDZ), Src homology 3 (SH3), and guanylate kinase (GUK) domain, but lack a large region in the N terminus encoded by one exon.
Title: Unraveling the genetic complexity of Drosophila stardust during photoreceptor morphogenesis and prevention of light-induced degeneration.
Interacts with Crumbs to control polarity of epithelia but not neuroblasts.
Title: Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.
recruitment of DLin-7 to MAGUK-based protein complexes is defined by cell-type specific mechanisms; DLin-7 acts downstream of Sdt in epithelia and downstream of Dlg at synapses
Title: Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables guanylate kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell junction assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IEP Inferred from Expression Pattern more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IPI Inferred from Physical Interaction more info	PubMed
NOT involved_in establishment or maintenance of neuroblast polarity	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in establishment or maintenance of neuroblast polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of polarity of embryonic epithelium	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of polarity of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in generation of neurons	IBA Inferred from Biological aspect of Ancestor more info
involved_in morphogenesis of a polarized epithelium	TAS Traceable Author Statement more info	PubMed
involved_in morphogenesis of an epithelial sheet	IBA Inferred from Biological aspect of Ancestor more info
involved_in morphogenesis of an epithelium	NAS Non-traceable Author Statement more info	PubMed
involved_in photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ubiquitin-dependent endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in zonula adherens assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in apical plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in septate junction	TAS Traceable Author Statement more info	PubMed
part_of subapical complex	IPI Inferred from Physical Interaction more info	PubMed
part_of subapical complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: stardust

Names: BP1063; CG32717-PB; CG32717-PD; CG32717-PE; CG32717-PF; CG32717-PG; CG32717-PH; CG32717-PI; CG32717-PJ; CG32717-PK; CG32717-PL; CG32717-PM; CG32717-PN; CG32717-PO; CG32717-PP; anon-fast-evolving-2E6; sdt-PB; sdt-PD; sdt-PE; sdt-PF; sdt-PG; sdt-PH; sdt-PI; sdt-PJ; sdt-PK; sdt-PL; sdt-PM; sdt-PN; sdt-PO; sdt-PP

NP_001033835.2

EC 2.7.4.8

NP_001033836.1

EC 2.7.4.8

NP_001036263.1

EC 2.7.4.8

NP_001245574.1

EC 2.7.4.8

NP_001245575.1

EC 2.7.4.8

NP_001245576.1

EC 2.7.4.8

NP_001259326.1

EC 2.7.4.8

NP_001259327.1

EC 2.7.4.8

NP_001285010.1

EC 2.7.4.8

NP_001285011.1

EC 2.7.4.8

NP_572463.1

EC 2.7.4.8

NP_572464.4

EC 2.7.4.8

NP_996375.1

EC 2.7.4.8

NP_996376.1

EC 2.7.4.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

8178549..8240474

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272397.1 → NP_001259326.1 stardust, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259326.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PJD0

Conserved Domains (5) summary

cd12036
Location:1554 → 1615

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:1712 → 1883

GuKc; Guanylate kinase homologues

cd00992
Location:1443 → 1521

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1701 → 1875

Guanylate_kin; Guanylate kinase

cl02672
Location:1304 → 1347

L27; L27 domain
NM_001298082.1 → NP_001285011.1 stardust, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285011.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JIZ6

Conserved Domains (5) summary

cd12036
Location:826 → 887

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:984 → 1155

GuKc; Guanylate kinase homologues

cd00992
Location:715 → 793

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:973 → 1147

Guanylate_kin; Guanylate kinase

cl02672
Location:576 → 619

L27; L27 domain
NM_001038746.3 → NP_001033835.2 stardust, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001033835.2

Status: REVIEWED

UniProtKB/TrEMBL

E2QD98

Conserved Domains (5) summary

cd12036
Location:1673 → 1734

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:1831 → 2002

GuKc; Guanylate kinase homologues

cd00992
Location:1562 → 1640

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1820 → 1994

Guanylate_kin; Guanylate kinase

cl02672
Location:1423 → 1466

L27; L27 domain
NM_001298081.1 → NP_001285010.1 stardust, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285010.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8WRS3, X2JCZ1

Conserved Domains (5) summary

cd12036
Location:1259 → 1320

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:1417 → 1588

GuKc; Guanylate kinase homologues

cd00992
Location:1148 → 1226

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1406 → 1580

Guanylate_kin; Guanylate kinase

cl02672
Location:1009 → 1052

L27; L27 domain
NM_001258647.1 → NP_001245576.1 stardust, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245576.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NEZ2

Conserved Domains (5) summary

cd12036
Location:1575 → 1636

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:1771 → 1923

GuKc; Guanylate kinase homologues

cd00992
Location:1464 → 1542

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1722 → 1915

Guanylate_kin; Guanylate kinase

cl02672
Location:1325 → 1368

L27; L27 domain
NM_001258645.1 → NP_001245574.1 stardust, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245574.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NG38

Conserved Domains (5) summary

cd12036
Location:1161 → 1222

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:1357 → 1509

GuKc; Guanylate kinase homologues

cd00992
Location:1050 → 1128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1308 → 1501

Guanylate_kin; Guanylate kinase

cl02672
Location:911 → 954

L27; L27 domain
NM_132235.5 → NP_572463.1 stardust, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572463.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8WRS3, Q9W3H6

Related

FBpp0088916

Conserved Domains (5) summary

cd12036
Location:945 → 1006

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:1103 → 1274

GuKc; Guanylate kinase homologues

cd00992
Location:834 → 912

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1092 → 1266

Guanylate_kin; Guanylate kinase

cl02672
Location:695 → 738

L27; L27 domain
NM_001038747.3 → NP_001033836.1 stardust, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001033836.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6NP43, Q6NR03

Conserved Domains (5) summary

cd12036
Location:512 → 573

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:670 → 841

GuKc; Guanylate kinase homologues

cd00992
Location:401 → 479

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:659 → 833

Guanylate_kin; Guanylate kinase

cl02672
Location:262 → 305

L27; L27 domain
NM_001272398.1 → NP_001259327.1 stardust, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259327.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8WRS3, Q9W3H6

Conserved Domains (5) summary

cd12036
Location:945 → 1006

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:1103 → 1274

GuKc; Guanylate kinase homologues

cd00992
Location:834 → 912

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1092 → 1266

Guanylate_kin; Guanylate kinase

cl02672
Location:695 → 738

L27; L27 domain
NM_206653.3 → NP_996376.1 stardust, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996376.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KVT3, Q8WRS3

Conserved Domains (5) summary

cd12036
Location:1020 → 1081

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:1178 → 1349

GuKc; Guanylate kinase homologues

cd00992
Location:909 → 987

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1167 → 1341

Guanylate_kin; Guanylate kinase

cl02672
Location:770 → 813

L27; L27 domain
NM_132236.6 → NP_572464.4 stardust, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572464.4

Status: REVIEWED

UniProtKB/TrEMBL

Q8WRS3, Q9W3H8

Conserved Domains (5) summary

cd12036
Location:922 → 983

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:1080 → 1251

GuKc; Guanylate kinase homologues

cd00992
Location:811 → 889

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1069 → 1243

Guanylate_kin; Guanylate kinase

cl02672
Location:672 → 715

L27; L27 domain
NM_001042798.2 → NP_001036263.1 stardust, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036263.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0KHU9

Conserved Domains (5) summary

cd12036
Location:587 → 648

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:745 → 916

GuKc; Guanylate kinase homologues

cd00992
Location:476 → 554

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:734 → 908

Guanylate_kin; Guanylate kinase

cl02672
Location:337 → 380

L27; L27 domain
NM_206652.2 → NP_996375.1 stardust, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996375.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6NP43, Q9W3H7

Conserved Domains (5) summary

cd12036
Location:532 → 593

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:690 → 861

GuKc; Guanylate kinase homologues

cd00992
Location:421 → 499

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:679 → 853

Guanylate_kin; Guanylate kinase

pfam02828
Location:282 → 325

L27; L27 domain
NM_001258646.1 → NP_001245575.1 stardust, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245575.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6NP43, Q9W3H7

Conserved Domains (5) summary

cd12036
Location:532 → 593

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:690 → 861

GuKc; Guanylate kinase homologues

cd00992
Location:421 → 499

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:679 → 853

Guanylate_kin; Guanylate kinase

pfam02828
Location:282 → 325

L27; L27 domain

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
E2QD98		E2QD98
M9NEZ2		M9NEZ2
M9NG38		M9NG38
M9PJD0		M9PJD0
Q0KHU9		Q0KHU9
Q6NR03		Q6NR03
Q7KVT3		Q7KVT3
Q8WRS2		Q8WRS2
Q8WRS3		Q8WRS3
Q9W3H6		Q9W3H6
Q9W3H7		Q9W3H7
Q9W3H8		Q9W3H8
X2JCZ1		X2JCZ1
X2JIZ6		X2JIZ6