Gr5a Gustatory receptor 5a [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gr5aprovided by FlyBase
Official Full Name: Gustatory receptor 5aprovided by FlyBase
Primary source: FLYBASE:FBgn0003747
Locus tag: Dmel_CG15779
See related: AllianceGenome:FB:FBgn0003747
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15779; Dmel5a; Dmel\CG15779; Gr5; GR5a; GR5A; Gr5A1; GRLU.7; GrLU7; han; LU.7; tre; Tre
Summary: Enables sweet taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of sweet taste; proboscis extension reflex; and response to trehalose. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult labellum sensillum; ganglia; gustatory sensory organ; organism subdivision; and sensory neurons. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 5A12-5A12; 1-12 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5680617..5682488)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5574650..5576521)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The detection of sugar via Gr5a gustatory receptor neurons is necessary for food-promoted male aggression.
Title: How food controls aggression in Drosophila.
necessary for normal trehalose detection
Title: Drosophila Gr5a: expression pattern, ligand profile and transduction pathway.
analysis of trehalose sensitivity of the gustatory receptor neurons expressing wild-type, mutant and ectopic Gr5a in Drosophila
Title: Trehalose sensitivity of the gustatory receptor neurons expressing wild-type, mutant and ectopic Gr5a in Drosophila.
The simplest interpretation of our results is that Gr5a and Gr64a are each capable of functioning independently of each other within individual sugar neurons and that they are the primary receptors used in the labellum to detect sugars.
Title: Two Gr genes underlie sugar reception in Drosophila.
Gustator receptors would be candidate sugar receptors because Gr5a-expressing cells function in the responses to attractive tastants.
Title: A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging.
expressed in neurons of taste sensilla located on the labellum and legs
Title: Drosophila Gr5a encodes a taste receptor tuned to trehalose.
single P-element insertions in the intergenic region between Gr5a and Tre1 exert complex pleiotropic effects on fitness traits, including selective nutrient intake, life span, and resistance to starvation and heat stress
Title: Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster.
Causes of the observed pattern of nucleotide variation in the gustatory receptor Gr5a gene.
Title: A single-amino-acid change of the gustatory receptor gene, Gr5a, has a major effect on trehalose sensitivity in a natural population of Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ligand-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables sweet taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sweet taste receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables taste receptor activity	IEA Inferred from Electronic Annotation more info
enables taste receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables taste receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables taste receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in detection of chemical stimulus involved in sensory perception of sweet taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of taste	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of taste	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in proboscis extension reflex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to trehalose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sweet taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sweet taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info