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Acam Androcam [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44913, updated on 4-Jan-2025

Summary

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Official Symbol
Acamprovided by FlyBase
Official Full Name
Androcamprovided by FlyBase
Primary source
FLYBASE:FBgn0011273
Locus tag
Dmel_CG17769
See related
AllianceGenome:FB:FBgn0011273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACaM; And; CalB; Camr97A; CG17769; Dmel\CG17769
Summary
Enables myosin VI head/neck binding activity. Predicted to be involved in microtubule cytoskeleton organization. Located in cytoplasm; investment cone; and nucleus. Part of myosin VI complex. Is expressed in organism and testis. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Acam in Genome Data Viewer
Location:
96F3-96F3; 3-89 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25811911..25813134)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21637633..21638856)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45652 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44949

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NMR chemical shift assignments for androcam, a testis-specific myosin VI light chain in D. melanogaster. Joshi MK, et al. Biomol NMR Assign, 2013 Oct. PMID 22706933
  2. ¹H, ¹⁵N and ¹³C chemical shifts of the D. melanogaster myosin VI light chain androcam in high calcium. Joshi MK, et al. Biomol NMR Assign, 2013 Oct. PMID 22706934
  3. Conformational and metal-binding properties of androcam, a testis-specific, calmodulin-related protein from Drosophila. Martin SR, et al. Protein Sci, 1999 Nov. PMID 10595548, Free PMC Article
  4. Androcam, a Drosophila calmodulin-related protein, is expressed specifically in the testis and decorates loop kl-3 of the Y chromosome. Lu AQ, et al. Mech Dev, 2000 Jun. PMID 10842068
  5. The Long 3'UTR mRNA of CaMKII Is Essential for Translation-Dependent Plasticity of Spontaneous Release in Drosophila melanogaster. Kuklin EA, et al. J Neurosci, 2017 Nov 1. PMID 28954869, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hydrogen/Deuterium Exchange Mass Spectrometry Provides Insights into the Role of Drosophila Testis-Specific Myosin VI Light Chain AndroCaM.
    Title: Hydrogen/Deuterium Exchange Mass Spectrometry Provides Insights into the Role of Drosophila Testis-Specific Myosin VI Light Chain AndroCaM.
  2. Drosophila CaMKII-null mutants remain viable throughout development, but the long 3'-untranslated region is necessary for modulating spontaneous neurotransmission.
    Title: The Long 3'UTR mRNA of CaMKII Is Essential for Translation-Dependent Plasticity of Spontaneous Release in Drosophila melanogaster.
  3. The androcam structure and its binding to the myosin VI structural (Insert 2) and regulatory (IQ) light chain sites are distinct from those of calmodulin.
    Title: Structure of androcam supports specialized interactions with myosin VI.
  4. acts as a myosin VI light chain in the Drosophila testis and may alter the regulation of myosin VI in this tissue
    Title: Androcam is a tissue-specific light chain for myosin VI in the Drosophila testis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin VI head/neck binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament-based movement IC
Inferred by Curator
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in investment cone IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin VI complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
androcam
Names
Acam-PA
Acam-PB
CG17769-PA
CG17769-PB
Calmodulin-related 97A
androcalmodulin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25811911..25813134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170266.1 → NP_001163737.1  androcam, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163737.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JIY2, P49258, Q9VBL9
    UniProtKB/TrEMBL
    A0A1B2AJ49
    Conserved Domains (1) summary
    PTZ00184
    Location:3 → 148
    PTZ00184; calmodulin; Provisional

  2. NM_057640.3 → NP_476988.1  androcam, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476988.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JIY2, P49258, Q9VBL9
    UniProtKB/TrEMBL
    A0A1B2AJ49
    Related
    FBpp0084278
    Conserved Domains (1) summary
    PTZ00184
    Location:3 → 148
    PTZ00184; calmodulin; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49258.2 P49258

Gene LinkOut

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