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BRCA1 BRCA1 DNA repair associated [ Pan troglodytes (chimpanzee) ]

Gene ID: 449497, updated on 10-Oct-2024

Summary

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Official Symbol
BRCA1provided by VGNC
Official Full Name
BRCA1 DNA repair associatedprovided by VGNC
Primary source
VGNC:VGNC:10506
Locus tag
CK820_G0038928
See related
Ensembl:ENSPTRG00000009236
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See BRCA1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 19 NC_072417.2 (25025791..25106592)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 17 NC_072415.1 (23210259..23291054)

Chromosome 19 - NC_072417.2Genomic Context describing neighboring genes Neighboring gene transmembrane protein 106A Neighboring gene NBR1 autophagy cargo receptor Neighboring gene uncharacterized LOC107969158 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene Rho family GTPase 2 Neighboring gene uncharacterized LOC112206032 Neighboring gene vesicle amine transport 1 Neighboring gene interferon induced protein 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition. Pavlicek A, et al. Hum Mol Genet, 2004 Nov 15. PMID 15385441
  2. Evolutionary sequence comparisons using high-density oligonucleotide arrays. Hacia JG, et al. Nat Genet, 1998 Feb. PMID 9462745
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein homolog
Names
RING-type E3 ubiquitin transferase BRCA1
breast cancer 1, early onset
NP_001038958.1
XP_009430355.4
XP_009430356.4
XP_009430359.4
XP_009430376.3
XP_024205855.2
XP_054525683.1
XP_054525684.1
XP_054525685.1
XP_054525686.1
XP_054525687.1
XP_054525688.1
XP_054525689.1
XP_054525690.1
XP_054525691.1
XP_054525692.1
XP_054525693.1
XP_054525694.1
XP_054525695.1
XP_054525696.1
XP_054525697.1
XP_054525698.1
XP_054525699.1
XP_054525700.1
XP_054525701.1
XP_054525702.1
XP_054525704.1
XP_054525705.1
XP_054525706.1
XP_054525707.1
XP_054525708.1
XP_054525709.1
XP_054525710.1
XP_054525711.1
XP_054525712.1
XP_054525713.1
XP_054525714.1
XP_054525715.1
XP_054525716.1
XP_054525717.1
XP_054525719.1
XP_054525720.1
XP_054525721.1
XP_054525722.1
XP_054525723.1
XP_054525724.1
XP_054525725.1
XP_054525727.1
XP_054525728.1
XP_054525729.1
XP_063654061.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045493.1 → NP_001038958.1  breast cancer type 1 susceptibility protein homolog

    See identical proteins and their annotated locations for NP_001038958.1

    Status: PROVISIONAL

    Source sequence(s)
    AY365046
    UniProtKB/TrEMBL
    K7CMM2
    Related
    ENSPTRP00000070120.1, ENSPTRT00000078560.1
    Conserved Domains (4) summary
    smart00292
    Location:1758 → 1842
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:1650 → 1724
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12820
    Location:345 → 507
    BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072417.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    25025791..25106592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054669720.2 → XP_054525695.1  breast cancer type 1 susceptibility protein homolog isoform X9

  2. XM_054669724.2 → XP_054525699.1  breast cancer type 1 susceptibility protein homolog isoform X11

  3. XM_054669726.2 → XP_054525701.1  breast cancer type 1 susceptibility protein homolog isoform X12

  4. XM_054669732.2 → XP_054525707.1  breast cancer type 1 susceptibility protein homolog isoform X15

  5. XM_009432080.5 → XP_009430355.4  breast cancer type 1 susceptibility protein homolog isoform X1

  6. XM_054669709.2 → XP_054525684.1  breast cancer type 1 susceptibility protein homolog isoform X2

  7. XM_054669711.2 → XP_054525686.1  breast cancer type 1 susceptibility protein homolog isoform X4

  8. XM_024350087.3 → XP_024205855.2  breast cancer type 1 susceptibility protein homolog isoform X6

  9. XM_009432081.5 → XP_009430356.4  breast cancer type 1 susceptibility protein homolog isoform X1

  10. XM_054669708.2 → XP_054525683.1  breast cancer type 1 susceptibility protein homolog isoform X2

  11. XM_054669712.2 → XP_054525687.1  breast cancer type 1 susceptibility protein homolog isoform X4

  12. XM_054669715.2 → XP_054525690.1  breast cancer type 1 susceptibility protein homolog isoform X6

  13. XM_054669735.2 → XP_054525710.1  breast cancer type 1 susceptibility protein homolog isoform X17

  14. XM_054669738.2 → XP_054525713.1  breast cancer type 1 susceptibility protein homolog isoform X19

  15. XM_054669739.2 → XP_054525714.1  breast cancer type 1 susceptibility protein homolog isoform X20

  16. XM_054669745.2 → XP_054525720.1  breast cancer type 1 susceptibility protein homolog isoform X22

  17. XM_009432084.5 → XP_009430359.4  breast cancer type 1 susceptibility protein homolog isoform X3

  18. XM_054669713.2 → XP_054525688.1  breast cancer type 1 susceptibility protein homolog isoform X5

  19. XM_054669716.2 → XP_054525691.1  breast cancer type 1 susceptibility protein homolog isoform X7

  20. XM_054669718.2 → XP_054525693.1  breast cancer type 1 susceptibility protein homolog isoform X8

  21. XM_054669710.2 → XP_054525685.1  breast cancer type 1 susceptibility protein homolog isoform X3

  22. XM_054669714.2 → XP_054525689.1  breast cancer type 1 susceptibility protein homolog isoform X5

  23. XM_054669717.2 → XP_054525692.1  breast cancer type 1 susceptibility protein homolog isoform X7

  24. XM_054669719.2 → XP_054525694.1  breast cancer type 1 susceptibility protein homolog isoform X8

  25. XM_054669737.2 → XP_054525712.1  breast cancer type 1 susceptibility protein homolog isoform X18

  26. XM_054669749.2 → XP_054525724.1  breast cancer type 1 susceptibility protein homolog isoform X25

  27. XM_054669736.2 → XP_054525711.1  breast cancer type 1 susceptibility protein homolog isoform X17

  28. XM_054669721.2 → XP_054525696.1  breast cancer type 1 susceptibility protein homolog isoform X9

  29. XM_054669725.2 → XP_054525700.1  breast cancer type 1 susceptibility protein homolog isoform X11

  30. XM_054669727.2 → XP_054525702.1  breast cancer type 1 susceptibility protein homolog isoform X12

  31. XM_054669733.2 → XP_054525708.1  breast cancer type 1 susceptibility protein homolog isoform X15

  32. XM_054669729.2 → XP_054525704.1  breast cancer type 1 susceptibility protein homolog isoform X13

  33. XM_054669722.2 → XP_054525697.1  breast cancer type 1 susceptibility protein homolog isoform X10

  34. XM_054669731.2 → XP_054525706.1  breast cancer type 1 susceptibility protein homolog isoform X14

  35. XM_054669734.2 → XP_054525709.1  breast cancer type 1 susceptibility protein homolog isoform X16

  36. XM_054669753.2 → XP_054525728.1  breast cancer type 1 susceptibility protein homolog isoform X27

  37. XM_009432101.5 → XP_009430376.3  breast cancer type 1 susceptibility protein homolog isoform X18

  38. XM_054669741.2 → XP_054525716.1  breast cancer type 1 susceptibility protein homolog isoform X21

  39. XM_054669744.2 → XP_054525719.1  breast cancer type 1 susceptibility protein homolog isoform X23

  40. XM_054669723.2 → XP_054525698.1  breast cancer type 1 susceptibility protein homolog isoform X10

  41. XM_054669730.2 → XP_054525705.1  breast cancer type 1 susceptibility protein homolog isoform X13

  42. XM_063797991.1 → XP_063654061.1  breast cancer type 1 susceptibility protein homolog isoform X19

  43. XM_054669740.2 → XP_054525715.1  breast cancer type 1 susceptibility protein homolog isoform X20

  44. XM_054669747.2 → XP_054525722.1  breast cancer type 1 susceptibility protein homolog isoform X22

  45. XM_054669750.2 → XP_054525725.1  breast cancer type 1 susceptibility protein homolog isoform X25

  46. XM_054669752.2 → XP_054525727.1  breast cancer type 1 susceptibility protein homolog isoform X26

  47. XM_054669754.2 → XP_054525729.1  breast cancer type 1 susceptibility protein homolog isoform X27

  48. XM_054669742.2 → XP_054525717.1  breast cancer type 1 susceptibility protein homolog isoform X21

  49. XM_054669746.2 → XP_054525721.1  breast cancer type 1 susceptibility protein homolog isoform X23

  50. XM_054669748.2 → XP_054525723.1  breast cancer type 1 susceptibility protein homolog isoform X24

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GKK8.2 GenPept UniProtKB/Swiss-Prot:Q9GKK8

Gene LinkOut

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Molecular Biology Databases
Research Materials