MT1H metallothionein 1H [Homo sapiens (human)] - Gene

Summary

Official Symbol: MT1Hprovided by HGNC
Official Full Name: metallothionein 1Hprovided by HGNC
Primary source: HGNC:HGNC:7400
See related: Ensembl:ENSG00000205358 MIM:156354; AllianceGenome:HGNC:7400
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MT1; MT-0; MT-1H; MT-IH
Summary: Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney (RPKM 179.8), small intestine (RPKM 88.9) and 6 other tissues See more
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Genomic context

Location:: 16q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (56669814..56671129)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (62464791..62466106)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (56703726..56705041)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that MT1H is downregulated in TCGA dataset and a panel of 12 paired tumor/non-tumor tissues. Ectopic overexpression of MT1H in HepG2 and Hep3B cells inhibited cell proliferation, invasion, and migration through inhibiting Wnt/beta-catenin pathway.
Title: Metallothionein 1H (MT1H) functions as a tumor suppressor in hepatocellular carcinoma through regulating Wnt/β-catenin signaling pathway.
MT1H was down-regulated in renal cell carcinogenesis.
Title: An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis.
Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia.
Title: Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.
S-nitrosothiols react preferentially with zinc thiolate clusters through transnitrosation.
Title: S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation.
Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Heavy metal binding activity.
Title: Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of a quantitative disordered gambling trait. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16S3240 (e-PCR)
- UniSTS:2114

SHGC-36986 (e-PCR)
- UniSTS:39276

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to cadmium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in detoxification of copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of growth	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: metallothionein-1H

Names: metallothionein-0; metallothionein-IH; testicular tissue protein Li 123

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.