Vha68-2 Vacuolar H[+] ATPase 68 kDa subunit 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vha68-2provided by FlyBase
Official Full Name: Vacuolar H[+] ATPase 68 kDa subunit 2provided by FlyBase
Primary source: FLYBASE:FBgn0263598
Locus tag: Dmel_CG3762
See related: AllianceGenome:FB:FBgn0263598
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A subunit; ATP6V1A; CG3762; Dmel\CG3762; l(2)01510; l(2)s4214; MENE-R6; RE30552p; VATA; Vha6-2; vha67-2; Vha68; vha68-2; Vha68.2
Summary: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in several processes, including endosomal lumen acidification; imaginal disc growth; and lumen formation, open tracheal system. Located in plasma membrane. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including circulatory system primordium; embryonic/larval midgut primordium; epithelium; gut section; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 34A3-34A3; 2-47 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (12974322..12978607)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (12974322..12978607)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
contributes_to proton-transporting ATPase activity, rotational mechanism	IC Inferred by Curator more info	PubMed
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in endosomal lumen acidification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lumen formation, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IC Inferred by Curator more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	HDA more info	PubMed
part_of plasma membrane proton-transporting V-type ATPase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of proton-transporting V-type ATPase, V1 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: vacuolar H[+] ATPase 68 kDa subunit 2

Names: CG3762-PA; CG3762-PB; CG3762-PC; CG3762-PD; CG3762-PE; CG3762-PF; V-ATPase 69 kDa subunit 2; V-ATPase V1 subunit A1; Vha68-2-PA; Vha68-2-PB; Vha68-2-PC; Vha68-2-PD; Vha68-2-PE; Vha68-2-PF; vacuolar ATPase; vacuolar H[+] ATPase subunit 68-2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

12974322..12978607

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273496.1 → NP_001260425.1 vacuolar H[+] ATPase 68 kDa subunit 2, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260425.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27331, Q8SXT2, Q9VK48

UniProtKB/TrEMBL

A4V0N4, V9GZU6

Conserved Domains (1) summary

TIGR01042
Location:16 → 606

V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
NM_143747.3 → NP_652004.2 vacuolar H[+] ATPase 68 kDa subunit 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652004.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27331, Q8SXT2, Q9VK48

UniProtKB/TrEMBL

A4V0N4, V9GZU6

Related

FBpp0079999

Conserved Domains (1) summary

TIGR01042
Location:16 → 606

V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
NM_165021.2 → NP_723775.1 vacuolar H[+] ATPase 68 kDa subunit 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723775.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27331, Q8SXT2, Q9VK48

UniProtKB/TrEMBL

A4V0N4, V9GZU6

Related

FBpp0080000

Conserved Domains (1) summary

TIGR01042
Location:16 → 606

V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
NM_165022.2 → NP_723776.1 vacuolar H[+] ATPase 68 kDa subunit 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723776.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27331, Q8SXT2, Q9VK48

UniProtKB/TrEMBL

A4V0N4, V9GZU6

Related

FBpp0080001

Conserved Domains (1) summary

TIGR01042
Location:16 → 606

V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
NM_001259086.2 → NP_001246015.1 vacuolar H[+] ATPase 68 kDa subunit 2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246015.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27331, Q8SXT2, Q9VK48

UniProtKB/TrEMBL

A4V0N4, V9GZU6

Conserved Domains (1) summary

TIGR01042
Location:16 → 606

V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
NM_001273495.1 → NP_001260424.1 vacuolar H[+] ATPase 68 kDa subunit 2, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260424.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27331, Q8SXT2, Q9VK48

UniProtKB/TrEMBL

A4V0N4, V9GZU6

Conserved Domains (1) summary

TIGR01042
Location:16 → 606

V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit