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Zfrp8 Zinc finger protein RP-8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45021, updated on 4-Jan-2025

Summary

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Official Symbol
Zfrp8provided by FlyBase
Official Full Name
Zinc finger protein RP-8provided by FlyBase
Primary source
FLYBASE:FBgn0021875
Locus tag
Dmel_CG3260
See related
AllianceGenome:FB:FBgn0021875
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
137/5; CG3260; Dmel\CG3260; l(2)k13705; PDCD2; zfrp8
Summary
Enables ribosomal small subunit binding activity. Involved in several processes, including embryonic hemopoiesis; regulation of cytoplasmic translation; and somatic stem cell division. Located in cytoplasm and nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; germarium; head mesoderm; and trunk mesoderm. Orthologous to human PDCD2 (programmed cell death 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Zfrp8 in Genome Data Viewer
Location:
60B11-60B12; 2-106 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24133989..24135405)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20021512..20022928)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tamo Neighboring gene long non-coding RNA:CR44826 Neighboring gene N(alpha)-acetyltransferase 35 Neighboring gene speck Neighboring gene DnaJ-like-60 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hematopoietic stem cells in Drosophila. Minakhina S, et al. Development, 2010 Jan. PMID 20023157, Free PMC Article
  2. Zfrp8/PDCD2 Interacts with RpS2 Connecting Ribosome Maturation and Gene-Specific Translation. Minakhina S, et al. PLoS One, 2016. PMID 26807849, Free PMC Article
  3. Zfrp8/PDCD2 is required in ovarian stem cells and interacts with the piRNA pathway machinery. Minakhina S, et al. Development, 2014 Jan. PMID 24381196, Free PMC Article
  4. Drosophila melanogaster as a Model to Study the Multiple Phenotypes, Related to Genome Stability of the Fragile-X Syndrome. Specchia V, et al. Front Genet, 2019. PMID 30815010, Free PMC Article
  5. Tamo selectively modulates nuclear import in Drosophila. Minakhina S, et al. Genes Cells, 2003 Apr. PMID 12653959

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results suggest that Zfrp8/PDCD2 functions at late stages of ribosome assembly and may regulate the binding of specific mRNA-RNPs to the small ribosomal subunit ultimately controlling their cytoplasmic localization and translation.
    Title: Zfrp8/PDCD2 Interacts with RpS2 Connecting Ribosome Maturation and Gene-Specific Translation.
  2. demonstrate that Zfrp8 genetically interacts with Fmr1 and tral in an antagonistic manner. Zfrp8 and FMRP both control heterochromatin packaging, also in opposite ways
    Title: Zfrp8 forms a complex with fragile-X mental retardation protein and regulates its localization and function.
  3. The piRNA pathway is essential in early oogenesis, and we find that nuclear localization of Zfrp8 in germline stem cells and their offspring is regulated by some piRNA pathway genes.
    Title: Zfrp8/PDCD2 is required in ovarian stem cells and interacts with the piRNA pathway machinery.
  4. Data find that the conserved factor Zfrp8/PDCD2 is essential for the maintenance of the hematopoietic stem cells, but dispensable for their daughter cells, the pluripotent precursors.
    Title: Hematopoietic stem cells in Drosophila.
  5. Zfrp8 is involved in the regulation of cell proliferation from embryonic stages onward, through the function of the centrosome, and regulates the level and localization of cell-cycle components
    Title: Zfrp8, the Drosophila ortholog of PDCD2, functions in lymph gland development and controls cell proliferation.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ribosomal small subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in somatic stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein RP-8
Names
CG3260-PA
CG3260-PB
Zfrp8-PA
Zfrp8-PB
programmed cell death 2
zinc finger RP8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24133989..24135405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138046.2 → NP_611890.1  zinc finger protein RP-8, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611890.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZ50, Q9W1A3
    Related
    FBpp0072162
    Conserved Domains (2) summary
    pfam01753
    Location:128 → 164
    zf-MYND; MYND finger
    pfam04194
    Location:238 → 340
    PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

  2. NM_001299899.1 → NP_001286828.1  zinc finger protein RP-8, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286828.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZ50, Q9W1A3
    Conserved Domains (2) summary
    pfam01753
    Location:128 → 164
    zf-MYND; MYND finger
    pfam04194
    Location:238 → 340
    PDCD2_C; Programmed cell death protein 2, C-terminal putative domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MZ50 Q8MZ50
Q9W1A3 Q9W1A3

Gene LinkOut

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