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Spn43Ab Serpin 43Ab [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45040, updated on 4-Jan-2025

Summary

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Official Symbol
Spn43Abprovided by FlyBase
Official Full Name
Serpin 43Abprovided by FlyBase
Primary source
FLYBASE:FBgn0024293
Locus tag
Dmel_CG1865
See related
AllianceGenome:FB:FBgn0024293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118057.2; CG1865; Dmel\CG1865; Ser2; SER2; spn43Ab
Summary
Involved in sexual reproduction. Predicted to be active in extracellular space. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); lung disease (multiple); retinal vascular disease (multiple); and thrombophilia (multiple). Orthologous to several human genes including SERPINA12 (serpin family A member 12); SERPINB1 (serpin family B member 1); and SERPINC1 (serpin family C member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Spn43Ab in Genome Data Viewer
Location:
42F3-42F3; 2-55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7151662..7153642, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3039167..3041147, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44200 Neighboring gene Serpin 43Aa Neighboring gene uncharacterized protein Neighboring gene Serpin 43Ad Neighboring gene prickle Neighboring gene necrotic

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2. Green C, et al. Genetics, 2000 Nov. PMID 11063688, Free PMC Article
  2. The microevolutionary response to male-limited X-chromosome evolution in Drosophila melanogaster reflects macroevolutionary patterns. Abbott JK, et al. J Evol Biol, 2020 Jun. PMID 32176391
  3. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. Gubb D, et al. Genes Dev, 1999 Sep 1. PMID 10485852, Free PMC Article
  4. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Levashina EA, et al. Science, 1999 Sep 17. PMID 10489372
  5. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase inhibitor activity IKR
Inferred from Key Residues
more info
 PubMed 
NOT enables serine-type endopeptidase inhibitor activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in sexual reproduction IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
serpin 43Ab
Names
CG1865-PB
Spn43Ab-PB
serine protease inhibitor 2
serine protease inhibitor 43Ab

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7151662..7153642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032224.2 → NP_001027395.1  serpin 43Ab [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027395.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6V5, Q9U5W8
    Conserved Domains (1) summary
    cd00172
    Location:30 → 387
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z6V5 A1Z6V5
Q9U5W8 Q9U5W8

Gene LinkOut

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