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Ggamma30A G protein gamma subunit 30A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45234, updated on 9-Dec-2024

Summary

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Official Symbol
Ggamma30Aprovided by FlyBase
Official Full Name
G protein gamma subunit 30Aprovided by FlyBase
Primary source
FLYBASE:FBgn0267252
Locus tag
Dmel_CG3694
See related
AllianceGenome:FB:FBgn0267252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18511; CG3694; CG43733; Dmel\CG3694; G-gamma30A; Galpha30A; Ggamma; Ggammae; Ggamma[[e]]; GNG gene like; G[[gamma30A]]; G[[gamma]]; lincRNA.S701
Old locus tag
Dmel_CG43733
Summary
Enables protein heterodimerization activity. Involved in G protein-coupled receptor signaling pathway; cellular response to carbon dioxide; and phototransduction. Located in cytoplasm and rhabdomere. Part of heterotrimeric G-protein complex. Is expressed in eye; organism subdivision; photoreceptor neurons; and synaptic neuropil domain. Orthologous to human GNG13 (G protein subunit gamma 13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ggamma30A in Genome Data Viewer
Location:
30A7-30A8; 2-35 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9256563..9302494)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9256563..9302494)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lectin-30A Neighboring gene long non-coding RNA:CR45262 Neighboring gene borealin-related Neighboring gene long non-coding RNA:CR42844 Neighboring gene long non-coding RNA:CR45456

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system. Schillo S, et al. J Biol Chem, 2004 Aug 27. PMID 15205461
  2. G-protein gamma subunit 1 is required for sugar reception in Drosophila. Ishimoto H, et al. EMBO J, 2005 Sep 21. PMID 16121192, Free PMC Article
  3. G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13). Blake BL, et al. J Biol Chem, 2001 Dec 28. PMID 11675383
  4. Dendrobium nobile Polysaccharide Attenuates Blue Light-Induced Injury in Retinal Cells and In Vivo in Drosophila. Hsu WH, et al. Antioxidants (Basel), 2024 May 14. PMID 38790708, Free PMC Article
  5. A novel Ggamma isolated from Drosophila constitutes a visual G protein gamma subunit of the fly compound eye. Schulz S, et al. J Biol Chem, 1999 Dec 31. PMID 10608815

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ggammae has a role in light sensitivity of the visual system
    Title: Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta-subunit binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to carbon dioxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phototransduction IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in sensory perception of taste IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
  
part_of heterotrimeric G-protein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in rhabdomere IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G protein gamma subunit 30A
Names
CG3694-PA
CG3694-PB
CG3694-PC
CG3694-PF
CG3694-PG
CG3694-PH
CG3694-PI
CG3694-PJ
G protein gamma30A
G protein subunit gamma at 30A
Ggamma30A-PA
Ggamma30A-PB
Ggamma30A-PC
Ggamma30A-PF
Ggamma30A-PG
Ggamma30A-PH
Ggamma30A-PI
Ggamma30A-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9256563..9302494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164852.3 → NP_723452.1  G protein gamma subunit 30A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723452.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
    UniProtKB/TrEMBL
    E1JHC3
    Related
    FBpp0079397
    Conserved Domains (1) summary
    cd00068
    Location:11 → 67
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

  2. NM_001169447.2 → NP_001162918.1  G protein gamma subunit 30A, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162918.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
    UniProtKB/TrEMBL
    E1JHC3
    Conserved Domains (1) summary
    cd00068
    Location:11 → 67
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

  3. NM_001298847.1 → NP_001285776.1  G protein gamma subunit 30A, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285776.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JDM7
    Conserved Domains (1) summary
    cd00068
    Location:11 → 67
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

  4. NM_080068.4 → NP_524807.1  G protein gamma subunit 30A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524807.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
    UniProtKB/TrEMBL
    E1JHC3
    Related
    FBpp0079395
    Conserved Domains (1) summary
    cd00068
    Location:11 → 67
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

  5. NM_001201820.2 → NP_001188749.1  G protein gamma subunit 30A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188749.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
    UniProtKB/TrEMBL
    E1JHC3
    Conserved Domains (1) summary
    cd00068
    Location:11 → 67
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

  6. NM_164851.3 → NP_723451.1  G protein gamma subunit 30A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723451.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
    UniProtKB/TrEMBL
    E1JHC3
    Related
    FBpp0079396
    Conserved Domains (1) summary
    cd00068
    Location:11 → 67
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

  7. NM_001259021.2 → NP_001245950.1  G protein gamma subunit 30A, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245950.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0H1, Q95RZ3, Q9NFZ3, Q9VLD3
    UniProtKB/TrEMBL
    E1JHC3
    Conserved Domains (1) summary
    cd00068
    Location:11 → 67
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

  8. NM_001169446.3 → NP_001162917.2  G protein gamma subunit 30A, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162917.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JHC4
    Conserved Domains (1) summary
    cd00068
    Location:3 → 59
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JHC3 E1JHC3
E1JHC4 E1JHC4
Q9NFZ3.1 Q9NFZ3
X2JDM7 X2JDM7

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