csw corkscrew [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cswprovided by FlyBase
Official Full Name: corkscrewprovided by FlyBase
Primary source: FLYBASE:FBgn0000382
Locus tag: Dmel_CG3954
See related: AllianceGenome:FB:FBgn0000382
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 19-106; anon-WO03040301.207; anon-WO03040301.209; anon-WO03040301.219; CG3954; Csw; CSW; csw/SHP-2; Csw/Shp2; Dmel\CG3954; E(sev)1A; EG:BACN25G24.2; l(1)2Db; l(1)2Dd; l(1)csw; l(1)G0170; l(1)GA114; Shp-2; SHP-2; Shp2/csw
Summary: Enables non-membrane spanning protein tyrosine phosphatase activity; phosphotyrosine residue binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including axis specification; cell surface receptor protein tyrosine kinase signaling pathway; and nervous system development. Predicted to be active in cytoplasm. Is expressed in organism. Used to study Noonan syndrome 1; juvenile myelomonocytic leukemia; and leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to several human genes including PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 2D1-2D2; 1-0.6 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2094234..2115701)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1988267..2009734)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTPN11/Corkscrew Activates Local Presynaptic Mapk Signaling to Regulate Synapsin, Synaptic Vesicle Pools, and Neurotransmission Strength, with a Dual Requirement in Neurons and Glia.
Title: PTPN11/Corkscrew Activates Local Presynaptic Mapk Signaling to Regulate Synapsin, Synaptic Vesicle Pools, and Neurotransmission Strength, with a Dual Requirement in Neurons and Glia.
Study shows that in Drosophila, the duration of resting intervals required for inducing long-term memory is regulated by activity levels of the protein tyrosine phosphatase corkscrew (CSW).
Title: The phosphatase SHP2 regulates the spacing effect for long-term memory induction.
LEOPARD syndrome mutations in csw gene have gain-of-function effects during Drosophila development.
Title: Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development.
Data show that Downstream-of-FGFR is a substrate for fibroblast growth factor receptors (FGFRs) and recruits Corkscrew, leading to FGF-induced cell migration and activation of the Ras/MAPK pathway.
Title: Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation.
Corkscrew/SHP-2 proteins control Sprouty phosphorylation and function
Title: Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases.
Signalling from the pTyr (YB) Neu (ErbB-2) autophosphorylation site was affected by a haplosufficiency in drk (Grb-2), and in genes thought to function downstream of Grb-2: dab, sos, csw (Shp-2), and dos (Gab-1).
Title: Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables non-membrane spanning protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables non-membrane spanning protein tyrosine phosphatase activity	NAS Non-traceable Author Statement more info	PubMed
enables phosphotyrosine residue binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphotyrosine residue binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in R7 cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dorsal/ventral axis specification, ovarian follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sevenless signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in sevenless signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sevenless signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal region determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in torso signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in torso signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral midline development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: corkscrew

Names: CG3954-PA; CG3954-PB; CG3954-PC; CG3954-PD; csw-PA; csw-PB; csw-PC; csw-PD; enhancer of sevenless 1A

NP_001259174.1

EC 3.1.3.-

EC 3.1.3.48

NP_477130.1

EC 3.1.3.-

EC 3.1.3.48

NP_477131.1

EC 3.1.3.-

EC 3.1.3.48

NP_726793.1

EC 3.1.3.-

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

2094234..2115701

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272245.1 → NP_001259174.1 corkscrew, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259174.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29349, Q24032, Q24033, Q8I074, Q8I0H8, Q8I0S4, Q8ISD5, Q8ISD6, Q9V3H1, Q9W524

UniProtKB/TrEMBL

M9PGI1

Conserved Domains (4) summary

cd09931
Location:163 → 260

SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

cd10340
Location:59 → 155

SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

smart00194
Location:279 → 697

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:496 → 696

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_057782.5 → NP_477130.1 corkscrew, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477130.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29349, Q24032, Q24033, Q8I074, Q8I0H8, Q8I0S4, Q8ISD5, Q8ISD6, Q9V3H1, Q9W524

Related

FBpp0070362

Conserved Domains (4) summary

cd09931
Location:110 → 207

SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

cd10340
Location:5 → 102

SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

smart00194
Location:226 → 644

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:443 → 643

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_057783.3 → NP_477131.1 corkscrew, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477131.1

Status: REVIEWED

UniProtKB/TrEMBL

L7XAI0

Related

FBpp0070363

Conserved Domains (3) summary

cd09931
Location:211 → 307

SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

smart00194
Location:326 → 744

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:543 → 743

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_166928.2 → NP_726793.1 corkscrew, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726793.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29349

Related

FBpp0070364

Conserved Domains (3) summary

smart00194
Location:67 → 485

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:284 → 484

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cl15255
Location:1 → 48

SH2; Src homology 2 (SH2) domain