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csw - corkscrew

Enables non-membrane spanning protein tyrosine phosphatase activity; phosphotyrosine residue binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including axis specification; cell surface receptor protein tyrosine kinase signaling pathway; and nervous system development. Predicted to be active in cytoplasm. Is expressed in organism. Used to study Noonan syndrome 1; juvenile myelomonocytic leukemia; and leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to several human genes including PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to csw

NCBI Orthologs

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Species Gene Architecture aa