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kn - knot

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of muscle attachment site; larval somatic muscle development; and regionalization. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic myoblast; larval neurons; larval somatic muscle cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in hypotonia, ataxia, and delayed development syndrome. Orthologous to several human genes including EBF1 (EBF transcription factor 1) and EBF3 (EBF transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa