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trol terribly reduced optic lobes [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45320, updated on 9-Dec-2024

Summary

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Official Symbol
trolprovided by FlyBase
Official Full Name
terribly reduced optic lobesprovided by FlyBase
Primary source
FLYBASE:FBgn0284408
Locus tag
Dmel_CG33950
See related
AllianceGenome:FB:FBgn0284408
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0153538.72; BcDNA:GM02481; CG12497; CG33675; CG33950; CG7981; CT23996; Dmel\CG33950; EG:BACR25B3.1; EG:BACR25B3.10; EG:BACR25B3.11; EG:BACR25B3.2; GC7891; l(1)3Ac; l(1)9-96; l(1)G0019; l(1)G0021; l(1)G0023; l(1)G0181; l(1)G0211; l(1)G0271; l(1)G0374; l(1)G0412; l(1)trol; l(1)VA51; l(1)zw1; l(1)zwl; MRE7; pcan; Pcan; Pcn; Perl; Perlecan; Trol; TROL; Trol-A; Trol-B; troll; Troll; zw-1; ZW-1; zw1
Summary
Involved in several processes, including axon development; maintenance of epithelial cell apical/basal polarity; and regulation of signal transduction. Located in basement membrane. Is expressed in several structures, including cardioblast; gut section; lineage NB3-1 primary motor neurons; neuron projection bundle; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See trol in Genome Data Viewer
Location:
3A3-3A4; 1-1 cM
Exon count:
57
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2470460..2545427, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2364493..2439443, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene technical knockout Neighboring gene brother of ihog Neighboring gene zeste Neighboring gene mir-4955 stem loop Neighboring gene Pigment-dispersing factor receptor Neighboring gene Vacuolar H[+] ATPase 36kD subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development.
    Title: Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development.
  2. Two different sources of Perlecan cooperate for its function in the basement membrane of the Drosophila wing imaginal disc.
    Title: Two different sources of Perlecan cooperate for its function in the basement membrane of the Drosophila wing imaginal disc.
  3. present evidence that the effect of Trol on blood cell differentiation is mediated by Hedgehog (Hh) signaling, which is known to be required to maintain an immature medullary zone
    Title: The proteoglycan Trol controls the architecture of the extracellular matrix and balances proliferation and differentiation of blood progenitors in the Drosophila lymph gland.
  4. perlecan is required for Sema-1a-PlexA-mediated repulsive guidance, revealing roles for extracellular matrix proteoglycans in modulating transmembrane guidance cue signaling during neural development
    Title: The extracellular matrix proteoglycan perlecan facilitates transmembrane semaphorin-mediated repulsive guidance.
  5. Trol function is not dedicated to a single molecular mechanism, but is capable of regulating different growth factor pathways depending on the cell-type and event underway
    Title: The Drosophila Perlecan gene trol regulates multiple signaling pathways in different developmental contexts.
  6. The results suggest that trol acts in the extracellular matrix and binds, stores, and sequesters external signals and, thereby, participates in the stage- and region-specific control of neuroblast proliferation.
    Title: Perlecan participates in proliferation activation of quiescent Drosophila neuroblasts.
  7. The intrinsic control over myogenic programs can only be overridden by FGF4 signals provided by the apical ectodermal ridge of a developing limb.
    Title: Intrinsic, Hox-dependent cues determine the fate of skeletal muscle precursors.
  8. Trol can mediate signaling through both of the FGF and Hedgehog pathways to control the onset of stem cell proliferation in the developing nervous system.
    Title: Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division.
  9. The interaction of perlecan and dystroglycan at the basal side of the epithelium promotes basal membrane differentiation and is required for maintenance of cell polarity in the follicle-cell epithelium.
    Title: Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in defasciculation of motor neuron axon IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of semaphorin-plexin signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to anesthetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
terribly reduced optic lobes
Names
CG33950-PAF
CG33950-PAG
CG33950-PAH
CG33950-PAI
CG33950-PAK
CG33950-PAL
CG33950-PAM
CG33950-PAN
CG33950-PAO
CG33950-PAP
CG33950-PAQ
CG33950-PAR
CG33950-PAS
CG33950-PAT
CG33950-PAU
CG33950-PAV
CG33950-PAW
CG33950-PAX
CG33950-PAY
CG33950-PAZ
CG33950-PBA
CG33950-PBB
CG33950-PBC
CG33950-PBD
CG33950-PBE
Trol/perlecan
dPerlecan
lethal (1) G0019
lethal (1) G0021
lethal (1) G0023
lethal (1) G0181
lethal (1) G0211
lethal (1) G0271
lethal (1) G0374
lethal (1) G0412
mRNA-like ncRNA in embryogenesis 7
perlecan
trol-PAF
trol-PAG
trol-PAH
trol-PAI
trol-PAK
trol-PAL
trol-PAM
trol-PAN
trol-PAO
trol-PAP
trol-PAQ
trol-PAR
trol-PAS
trol-PAT
trol-PAU
trol-PAV
trol-PAW
trol-PAX
trol-PAY
trol-PAZ
trol-PBA
trol-PBB
trol-PBC
trol-PBD
trol-PBE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2470460..2545427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258565.3 → NP_001245494.2  terribly reduced optic lobes, isoform AY [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245494.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFR6
    Conserved Domains (15) summary
    cd05743
    Location:956 → 1031
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2553 → 2615
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:726 → 803
    IG; Immunoglobulin
    smart00410
    Location:2456 → 2534
    IG_like; Immunoglobulin like
    cd00054
    Location:3598 → 3630
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1666 → 1715
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3138 → 3283
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:861 → 895
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2537 → 2625
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3306 → 3338
    EGF; EGF-like domain
    pfam00052
    Location:1495 → 1620
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1751 → 1781
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:3669 → 3798
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2071 → 2153
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2468 → 2535
    Ig; Immunoglobulin domain

  2. NM_001297894.2 → NP_001284823.1  terribly reduced optic lobes, isoform AV [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284823.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPN3, X2JE09
    Conserved Domains (15) summary
    cd05743
    Location:1034 → 1109
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2693 → 2755
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:804 → 881
    IG; Immunoglobulin
    smart00410
    Location:2596 → 2674
    IG_like; Immunoglobulin like
    cd00054
    Location:3738 → 3770
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1744 → 1793
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3278 → 3423
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:939 → 973
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2677 → 2765
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3446 → 3478
    EGF; EGF-like domain
    pfam00052
    Location:1573 → 1698
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1829 → 1859
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:3809 → 3938
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2211 → 2293
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2608 → 2675
    Ig; Immunoglobulin domain

  3. NM_001103399.4 → NP_001096869.3  terribly reduced optic lobes, isoform AZ [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096869.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A023GRW4, Q8MPN3
    Conserved Domains (12) summary
    cd05743
    Location:1112 → 1187
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00410
    Location:2909 → 2985
    IG_like; Immunoglobulin like
    cd00054
    Location:3462 → 3495
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1822 → 1871
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3294 → 3439
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:1017 → 1051
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00053
    Location:1907 → 1937
    Laminin_EGF; Laminin EGF domain
    pfam07679
    Location:2617 → 2690
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2622 → 2626
    Ig; Ig strand B [structural motif]
    pfam00052
    Location:1651 → 1787
    Laminin_B; Laminin B (Domain IV)
    pfam13927
    Location:2514 → 2585
    Ig_3; Immunoglobulin domain
    cl11960
    Location:2693 → 2781
    Ig; Immunoglobulin domain

  4. NM_001297893.2 → NP_001284822.1  terribly reduced optic lobes, isoform AS [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284822.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JDK9
    Conserved Domains (12) summary
    cd05743
    Location:928 → 1003
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00410
    Location:2725 → 2801
    IG_like; Immunoglobulin like
    cd00054
    Location:3278 → 3311
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1638 → 1687
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3110 → 3255
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:833 → 867
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00053
    Location:1723 → 1753
    Laminin_EGF; Laminin EGF domain
    pfam07679
    Location:2433 → 2506
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2438 → 2442
    Ig; Ig strand B [structural motif]
    pfam00052
    Location:1467 → 1603
    Laminin_B; Laminin B (Domain IV)
    pfam13927
    Location:2330 → 2401
    Ig_3; Immunoglobulin domain
    cl11960
    Location:2509 → 2597
    Ig; Immunoglobulin domain

  5. NM_001031864.4 → NP_001027035.3  terribly reduced optic lobes, isoform AO [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027035.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRV8
    Conserved Domains (15) summary
    cd05743
    Location:1010 → 1085
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2607 → 2669
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:780 → 857
    IG; Immunoglobulin
    smart00410
    Location:2510 → 2588
    IG_like; Immunoglobulin like
    cd00054
    Location:3652 → 3684
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1720 → 1769
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3192 → 3337
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:915 → 949
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2591 → 2679
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3360 → 3392
    EGF; EGF-like domain
    pfam00052
    Location:1549 → 1674
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1805 → 1835
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:3723 → 3852
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2125 → 2207
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2522 → 2589
    Ig; Immunoglobulin domain

  6. NM_001297896.2 → NP_001284825.1  terribly reduced optic lobes, isoform BA [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284825.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPN3, X2JCE8
    Conserved Domains (15) summary
    cd05743
    Location:1326 → 1401
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2923 → 2985
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:1096 → 1173
    IG; Immunoglobulin
    smart00410
    Location:2826 → 2904
    IG_like; Immunoglobulin like
    cd00054
    Location:3968 → 4000
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:2036 → 2085
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3508 → 3653
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:1231 → 1265
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2907 → 2995
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3676 → 3708
    EGF; EGF-like domain
    pfam00052
    Location:1865 → 1990
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:2121 → 2151
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:4039 → 4168
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2441 → 2523
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2838 → 2905
    Ig; Immunoglobulin domain

  7. NM_001258570.3 → NP_001245499.2  terribly reduced optic lobes, isoform AQ [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245499.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFS1, Q8MPN3
    Conserved Domains (14) summary
    cd05743
    Location:1422 → 1497
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:3019 → 3081
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:1192 → 1269
    IG; Immunoglobulin
    smart00410
    Location:2922 → 3000
    IG_like; Immunoglobulin like
    cd00055
    Location:2132 → 2181
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3604 → 3749
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:1327 → 1361
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:3003 → 3091
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3772 → 3804
    EGF; EGF-like domain
    pfam00052
    Location:1961 → 2086
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:2217 → 2247
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:4135 → 4264
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2537 → 2619
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2934 → 3001
    Ig; Immunoglobulin domain

  8. NM_001258564.3 → NP_001245493.2  terribly reduced optic lobes, isoform AF [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245493.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDL5, Q8MPN3
    Conserved Domains (14) summary
    cd05743
    Location:1495 → 1570
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:3154 → 3216
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:1265 → 1342
    IG; Immunoglobulin
    smart00410
    Location:3057 → 3135
    IG_like; Immunoglobulin like
    cd00055
    Location:2205 → 2254
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3739 → 3884
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:1400 → 1434
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:3138 → 3226
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3907 → 3939
    EGF; EGF-like domain
    pfam00052
    Location:2034 → 2159
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:2290 → 2320
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:4270 → 4399
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2672 → 2754
    Ig_2; Immunoglobulin domain
    cl11960
    Location:3069 → 3136
    Ig; Immunoglobulin domain

  9. NM_001031862.4 → NP_001027033.3  terribly reduced optic lobes, isoform AW [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027033.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUV8, Q8IRV9, Q8MPN3
    Conserved Domains (15) summary
    cd05743
    Location:1130 → 1205
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2727 → 2789
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:900 → 977
    IG; Immunoglobulin
    smart00410
    Location:2630 → 2708
    IG_like; Immunoglobulin like
    cd00054
    Location:3772 → 3804
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1840 → 1889
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3312 → 3457
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:1035 → 1069
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2711 → 2799
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3480 → 3512
    EGF; EGF-like domain
    pfam00052
    Location:1669 → 1794
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1925 → 1955
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:3843 → 3972
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2245 → 2327
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2642 → 2709
    Ig; Immunoglobulin domain

  10. NM_001258562.3 → NP_001245491.2  terribly reduced optic lobes, isoform AU [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245491.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NES6, Q8MPN3
    Conserved Domains (14) summary
    cd05743
    Location:1574 → 1649
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:3171 → 3233
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:1344 → 1421
    IG; Immunoglobulin
    smart00410
    Location:3074 → 3152
    IG_like; Immunoglobulin like
    cd00055
    Location:2284 → 2333
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3756 → 3901
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:1479 → 1513
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:3155 → 3243
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3924 → 3956
    EGF; EGF-like domain
    pfam00052
    Location:2113 → 2238
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:2369 → 2399
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:4287 → 4416
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2689 → 2771
    Ig_2; Immunoglobulin domain
    cl11960
    Location:3086 → 3153
    Ig; Immunoglobulin domain

  11. NM_001258563.3 → NP_001245492.2  terribly reduced optic lobes, isoform AL [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245492.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NGK3
    Conserved Domains (15) summary
    cd05743
    Location:851 → 926
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2448 → 2510
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:621 → 698
    IG; Immunoglobulin
    smart00410
    Location:2351 → 2429
    IG_like; Immunoglobulin like
    cd00054
    Location:3493 → 3525
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1561 → 1610
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3033 → 3178
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:756 → 790
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2432 → 2520
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3201 → 3233
    EGF; EGF-like domain
    pfam00052
    Location:1390 → 1515
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1646 → 1676
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:3564 → 3693
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:1966 → 2048
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2363 → 2430
    Ig; Immunoglobulin domain

  12. NM_001414087.1 → NP_001401050.1  terribly reduced optic lobes, isoform BE [Drosophila melanogaster]

    Status: REVIEWED

  13. NM_001258567.3 → NP_001245496.2  terribly reduced optic lobes, isoform AI [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245496.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NET2
    Conserved Domains (15) summary
    cd05743
    Location:881 → 956
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2478 → 2540
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:2678 → 2754
    IG; Immunoglobulin
    smart00410
    Location:2381 → 2459
    IG_like; Immunoglobulin like
    cd00054
    Location:3662 → 3694
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1591 → 1640
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3202 → 3347
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:786 → 820
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2462 → 2550
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3370 → 3402
    EGF; EGF-like domain
    pfam00052
    Location:1420 → 1545
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1676 → 1706
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:3733 → 3862
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:1996 → 2078
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2393 → 2460
    Ig; Immunoglobulin domain

  14. NM_001258569.3 → NP_001245498.2  terribly reduced optic lobes, isoform AP [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245498.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDM1
    Conserved Domains (15) summary
    cd05743
    Location:929 → 1004
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2526 → 2588
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:699 → 776
    IG; Immunoglobulin
    smart00410
    Location:2429 → 2507
    IG_like; Immunoglobulin like
    cd00054
    Location:3571 → 3603
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1639 → 1688
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3111 → 3256
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:834 → 868
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2510 → 2598
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3279 → 3311
    EGF; EGF-like domain
    pfam00052
    Location:1468 → 1593
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1724 → 1754
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:3642 → 3771
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2044 → 2126
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2441 → 2508
    Ig; Immunoglobulin domain

  15. NM_001258568.3 → NP_001245497.2  terribly reduced optic lobes, isoform AM [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245497.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NGL3, Q8MPN3
    Conserved Domains (15) summary
    cd05743
    Location:1090 → 1165
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2687 → 2749
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:860 → 937
    IG; Immunoglobulin
    smart00410
    Location:2590 → 2668
    IG_like; Immunoglobulin like
    cd00054
    Location:3732 → 3764
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1800 → 1849
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3272 → 3417
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:995 → 1029
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2671 → 2759
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3440 → 3472
    EGF; EGF-like domain
    pfam00052
    Location:1629 → 1754
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1885 → 1915
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:3803 → 3932
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2205 → 2287
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2602 → 2669
    Ig; Immunoglobulin domain

  16. NM_001258571.3 → NP_001245500.2  terribly reduced optic lobes, isoform AR [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245500.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NE61, Q8MPN3
    Conserved Domains (15) summary
    cd05743
    Location:1273 → 1348
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2870 → 2932
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:1043 → 1120
    IG; Immunoglobulin
    smart00410
    Location:2773 → 2851
    IG_like; Immunoglobulin like
    cd00054
    Location:3915 → 3947
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1983 → 2032
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3455 → 3600
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:1178 → 1212
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2854 → 2942
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3623 → 3655
    EGF; EGF-like domain
    pfam00052
    Location:1812 → 1937
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:2068 → 2098
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:3986 → 4115
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2388 → 2470
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2785 → 2852
    Ig; Immunoglobulin domain

  17. NM_001169177.4 → NP_001162648.3  terribly reduced optic lobes, isoform AH [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162648.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJC0, Q8MPN3
    Conserved Domains (14) summary
    cd05743
    Location:1534 → 1609
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:3131 → 3193
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:1304 → 1381
    IG; Immunoglobulin
    smart00410
    Location:3034 → 3112
    IG_like; Immunoglobulin like
    cd00055
    Location:2244 → 2293
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3716 → 3861
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:1439 → 1473
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:3115 → 3203
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3884 → 3916
    EGF; EGF-like domain
    pfam00052
    Location:2073 → 2198
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:2329 → 2359
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:4247 → 4376
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2649 → 2731
    Ig_2; Immunoglobulin domain
    cl11960
    Location:3046 → 3113
    Ig; Immunoglobulin domain

  18. NM_001414086.1 → NP_001401049.1  terribly reduced optic lobes, isoform BD [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPN3

  19. NM_001258566.4 → NP_001245495.2  terribly reduced optic lobes, isoform AK [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245495.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NE56, Q8MPN3
    Conserved Domains (14) summary
    cd05743
    Location:1237 → 1312
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2896 → 2958
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:1007 → 1084
    IG; Immunoglobulin
    smart00410
    Location:2799 → 2877
    IG_like; Immunoglobulin like
    cd00055
    Location:1947 → 1996
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3481 → 3626
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:1142 → 1176
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2880 → 2968
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3649 → 3681
    EGF; EGF-like domain
    pfam00052
    Location:1776 → 1901
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:2032 → 2062
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:4012 → 4141
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2414 → 2496
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2811 → 2878
    Ig; Immunoglobulin domain

  20. NM_001031863.5 → NP_001027034.2  terribly reduced optic lobes, isoform BB [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KVZ0, Q8MPN3
    Conserved Domains (13) summary
    cd05743
    Location:1301 → 1376
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3395 → 3461
    IG; Immunoglobulin
    smart00410
    Location:3098 → 3174
    IG_like; Immunoglobulin like
    cd00055
    Location:2011 → 2060
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3483 → 3628
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:1206 → 1240
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00052
    Location:1840 → 1976
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:2096 → 2126
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:4014 → 4143
    Laminin_G_2; Laminin G domain
    pfam07679
    Location:2806 → 2879
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2607 → 2675
    Ig_3; Immunoglobulin domain
    cd00096
    Location:2811 → 2818
    Ig; Ig strand B [structural motif]
    cl11960
    Location:2882 → 2970
    Ig; Immunoglobulin domain

  21. NM_001031866.4 → NP_001027037.3  terribly reduced optic lobes, isoform AN [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027037.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPN3, Q9W4Y4
    Conserved Domains (15) summary
    cd05743
    Location:1273 → 1348
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2870 → 2932
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:1043 → 1120
    IG; Immunoglobulin
    smart00410
    Location:2773 → 2851
    IG_like; Immunoglobulin like
    cd00054
    Location:3915 → 3947
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1983 → 2032
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3455 → 3600
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:1178 → 1212
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2854 → 2942
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3623 → 3655
    EGF; EGF-like domain
    pfam00052
    Location:1812 → 1937
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:2068 → 2098
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:3986 → 4115
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2388 → 2470
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2785 → 2852
    Ig; Immunoglobulin domain

  22. NM_001031867.4 → NP_001027038.3  terribly reduced optic lobes, isoform AT [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027038.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPN3, Q9W4Y3
    Conserved Domains (14) summary
    cd05743
    Location:1574 → 1649
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:3171 → 3233
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:1344 → 1421
    IG; Immunoglobulin
    smart00410
    Location:3074 → 3152
    IG_like; Immunoglobulin like
    cd00055
    Location:2284 → 2333
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3784 → 3929
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:1479 → 1513
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:3155 → 3243
    I-set; Immunoglobulin I-set domain
    pfam00008
    Location:3952 → 3984
    EGF; EGF-like domain
    pfam00052
    Location:2113 → 2238
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:2369 → 2399
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:4315 → 4444
    Laminin_G_2; Laminin G domain
    pfam13895
    Location:2689 → 2771
    Ig_2; Immunoglobulin domain
    cl11960
    Location:3086 → 3153
    Ig; Immunoglobulin domain

  23. NM_001382068.1 → NP_001368970.1  terribly reduced optic lobes, isoform BC [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6H2EG25
    Conserved Domains (14) summary
    cd05743
    Location:881 → 956
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:2678 → 2754
    IG; Immunoglobulin
    smart00410
    Location:3114 → 3180
    IG_like; Immunoglobulin like
    cd00054
    Location:3370 → 3403
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1591 → 1640
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3202 → 3347
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:786 → 820
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00052
    Location:1420 → 1556
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1676 → 1706
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:3733 → 3862
    Laminin_G_2; Laminin G domain
    pfam07679
    Location:2386 → 2459
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2187 → 2255
    Ig_3; Immunoglobulin domain
    cd00096
    Location:2391 → 2398
    Ig; Ig strand B [structural motif]
    cl11960
    Location:2462 → 2550
    Ig; Immunoglobulin domain

  24. NM_001297895.2 → NP_001284824.1  terribly reduced optic lobes, isoform AX [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284824.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JAC7
    Conserved Domains (11) summary
    cd05743
    Location:878 → 953
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2475 → 2537
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:2769 → 2830
    IG; Immunoglobulin
    smart00410
    Location:2378 → 2456
    IG_like; Immunoglobulin like
    cd00055
    Location:1588 → 1637
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00112
    Location:783 → 817
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2459 → 2547
    I-set; Immunoglobulin I-set domain
    pfam00052
    Location:1417 → 1542
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1673 → 1703
    Laminin_EGF; Laminin EGF domain
    pfam13895
    Location:1993 → 2075
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2390 → 2457
    Ig; Immunoglobulin domain

  25. NM_001031865.4 → NP_001027036.3  terribly reduced optic lobes, isoform AG [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027036.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRV7
    Conserved Domains (11) summary
    cd05743
    Location:1130 → 1205
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:2727 → 2789
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:3021 → 3082
    IG; Immunoglobulin
    smart00410
    Location:2630 → 2708
    IG_like; Immunoglobulin like
    cd00055
    Location:1840 → 1889
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00112
    Location:1035 → 1069
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:2711 → 2799
    I-set; Immunoglobulin I-set domain
    pfam00052
    Location:1669 → 1794
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1925 → 1955
    Laminin_EGF; Laminin EGF domain
    pfam13895
    Location:2245 → 2327
    Ig_2; Immunoglobulin domain
    cl11960
    Location:2642 → 2709
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A023GRW4 A0A023GRW4
A0A6H2EG25 A0A6H2EG25
E1JJC0 E1JJC0
M9NDL5 M9NDL5
M9NDM1 M9NDM1
M9NE56 M9NE56
M9NE61 M9NE61
M9NES6 M9NES6
M9NET2 M9NET2
M9NFR6 M9NFR6
M9NFS1 M9NFS1
M9NGK3 M9NGK3
M9NGL3 M9NGL3
Q7KVZ0 Q7KVZ0
Q8IRV7 Q8IRV7
Q8IRV8 Q8IRV8
Q8IRV9 Q8IRV9
Q8MPN3 Q8MPN3
Q8MRK1 Q8MRK1
Q8MSR5 Q8MSR5
Q95S84 Q95S84
Q9NEF8 Q9NEF8
Q9NEF9 Q9NEF9
Q9NEG0 Q9NEG0
Q9NEG1 Q9NEG1
Q9NFS9 Q9NFS9
Q9W4Y3 Q9W4Y3
Q9W4Y4 Q9W4Y4
X2JAC7 X2JAC7
X2JCE8 X2JCE8
X2JDK9 X2JDK9
X2JE09 X2JE09

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