sens senseless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sensprovided by FlyBase
Official Full Name: senselessprovided by FlyBase
Primary source: FLYBASE:FBgn0002573
Locus tag: Dmel_CG32120
See related: AllianceGenome:FB:FBgn0002573
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1228/04; CG10714; CG32120; Dmel\CG32120; Gfi1; l(3)70Ad; Ly; Ly-1; sen; Sen; Sens; SENS; sense; Senseless; Ss
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; bHLH transcription factor binding activity; and sequence-specific DNA binding activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including chaeta morphogenesis; neuron development; and sensory organ precursor cell fate determination. Located in chromatin and nucleus. Is expressed in several structures, including embryonic segment; imaginal disc; peripheral sensory precursor cell; sense organ; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 70A8-70A8; 3-40 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (13396228..13401125, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (13389328..13394225, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell visualization of mir-9a and Senseless co-expression during Drosophila melanogaster embryonic and larval peripheral nervous system development.
Title: Single-cell visualization of mir-9a and Senseless co-expression during Drosophila melanogaster embryonic and larval peripheral nervous system development.
The CSN suppresses Sens through repression of the ecdysone signaling target gene broad (br) that encodes the BR-Z1 transcription factor to activate sens expression
Title: The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence.
Using multigenerational selection experiments, study finds that for the Drosophila proneural network, the effect of genomic diversity is dampened by miR-9a-mediated regulation of senseless expression.
Title: miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor.
propose that SUMOylation of Senseless via lysine 509 promotes its synergy with proneural proteins during transcriptional activation and hence regulates an important step in neurogenesis leading to the formation and maturation of the sense organ precursors
Title: The SUMO pathway promotes basic helix-loop-helix proneural factor activity via a direct effect on the Zn finger protein senseless.
Data found that expression of Wg target gene senseless (sens) was elevated in the sulf1 mutant wing discs. Sulf1 also negatively regulate extracellular levels of Wg.
Title: Sulfated is a negative feedback regulator of wingless in Drosophila.
Ato and Sens selectively enhance abdominal SOP development in a Spitz-independent manner, suggesting additional genetic interactions between this proneural pathway and Abd-A.
Title: Proneural and abdominal Hox inputs synergize to promote sensory organ formation in the Drosophila abdomen.
new model for R8 photoreceptor selection in which lateral inhibition establishes a transient pattern of selected R8s that is permanently reinforced by a repressive bistable loop between sens and ro
Title: Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate.
Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of sens are reported.
Title: Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of Senseless.
Hox-Senseless antagonism forms a molecular switch that integrates neural and anterior-posterior positional information.
Title: Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS.
senseless is the primary target of achaete and scute during interommatidial bristle development
Title: Senseless is required for pupal retinal development in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables bHLH transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in photoreceptor cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: senseless

Names: CG32120-PA; lyra; sens-PA; sensesless; sensless

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

13396228..13401125 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080079.3 → NP_524818.1 senseless [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524818.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q4V6Z2, Q9N658

UniProtKB/TrEMBL

Q4QPR0

Related

FBpp0075596

Conserved Domains (4) summary

COG5048
Location:423 → 497

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:415 → 435

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:413 → 435

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:455 → 480

zf-H2C2_2; Zinc-finger double domain