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ogre optic ganglion reduced [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45382, updated on 4-Jan-2025

Summary

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Official Symbol
ogreprovided by FlyBase
Official Full Name
optic ganglion reducedprovided by FlyBase
Primary source
FLYBASE:FBgn0004646
Locus tag
Dmel_CG3039
See related
AllianceGenome:FB:FBgn0004646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cb-8; CB8; CG3039; Dm-inx1; Dmel\CG3039; FBpp0070995; inx-1; inx1; Inx1; jnL3; l(1)6Ec; l(1)jnL3; l(1)ogre; Ogre
Summary
Predicted to enable gap junction channel activity. Involved in phototransduction, visible light. Located in basolateral plasma membrane and gap junction. Is expressed in several structures, including adult head; clypeo-labral primordium; epithelium; gut section; and head epidermis primordium. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See ogre in Genome Data Viewer
Location:
6E4-6E4; 1-18 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6973620..6991318, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6867653..6885351, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44084 Neighboring gene boudin Neighboring gene Innexin 7 Neighboring gene long non-coding RNA:CR43837

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The l(1)ogre gene of Drosophila melanogaster is expressed in postembryonic neuroblasts. Watanabe T, et al. Dev Biol, 1992 Jul. PMID 1628755
  2. Poly(dC) segments and cloning artifacts in databases. Paricio N, et al. Genetics, 1995 Jan. PMID 7705649, Free PMC Article
  3. Analysis of a cDNA from the neurologically active locus shaking-B (Passover) of Drosophila melanogaster. Crompton DE, et al. Gene, 1992 Dec 15. PMID 1487155
  4. Innexins Ogre and Inx2 are required in glial cells for normal postembryonic development of the Drosophila central nervous system. Holcroft CE, et al. J Cell Sci, 2013 Sep 1. PMID 23813964
  5. Gastrointestinal development in the Drosophila embryo requires the activity of innexin gap junction channel proteins. Bauer R, et al. Cell Commun Adhes, 2001. PMID 12064608

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of either ogre or inx2 selectively in glia, by targeted expression of RNA interference transgenes, leads to a significant reduction in the size of the larval nervous system and behavioural defects in surviving adults.
    Title: Innexins Ogre and Inx2 are required in glial cells for normal postembryonic development of the Drosophila central nervous system.
  2. Data propose that Inx3 is a critical factor for dorsal closure and that it mediates the stability of Inx1, 2 and DE-cadherin by forming a complex.
    Title: Innexin 3, a new gene required for dorsal closure in Drosophila embryo.
  3. innexin 1 predominantly localized to the baso-lateral domain of follicle cells.
    Title: Gap junctions in the ovary of Drosophila melanogaster: localization of innexins 1, 2, 3 and 4 and evidence for intercellular communication via innexin-2 containing channels.
  4. Data show that innexins, including shakB and ogre, are not functionally interchangeable in Drosophila during photoreceptor development.
    Title: Gap junction proteins are not interchangeable in development of neural function in the Drosophila visual system.
  5. role of the innexin 2 and ogre genes during gastrointestinal development of the fly embryo
    Title: Gastrointestinal development in the Drosophila embryo requires the activity of innexin gap junction channel proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gap junction channel activity IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in intercellular transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction, visible light IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in visual behavior ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in gap junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in gap junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
optic ganglion reduced
Names
CG3039-PA
CG3039-PB
CG3039-PC
CG3039-PD
CG3039-PE
CG3039-PF
contrast-blind-8
innexin 1
innexin-1
ogre-PA
ogre-PB
ogre-PC
ogre-PD
ogre-PE
ogre-PF
optic ganglia-reduced

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6973620..6991318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258628.3 → NP_001245557.1  optic ganglion reduced, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245557.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27716, Q0KHV4, Q9W3T8
    UniProtKB/TrEMBL
    M9PGW0
    Conserved Domains (1) summary
    pfam00876
    Location:20 → 351
    Innexin; Innexin

  2. NM_001258629.2 → NP_001245558.1  optic ganglion reduced, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245558.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27716, Q0KHV4, Q9W3T8
    UniProtKB/TrEMBL
    M9PGW0
    Conserved Domains (1) summary
    pfam00876
    Location:20 → 351
    Innexin; Innexin

  3. NM_001272371.1 → NP_001259300.1  optic ganglion reduced, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259300.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27716, Q0KHV4, Q9W3T8
    UniProtKB/TrEMBL
    M9PGW0
    Conserved Domains (1) summary
    pfam00876
    Location:20 → 351
    Innexin; Innexin

  4. NM_080085.5 → NP_524824.1  optic ganglion reduced, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524824.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27716, Q0KHV4, Q9W3T8
    UniProtKB/TrEMBL
    M9PGW0
    Related
    FBpp0070995
    Conserved Domains (1) summary
    pfam00876
    Location:20 → 351
    Innexin; Innexin

  5. NM_167101.3 → NP_727147.1  optic ganglion reduced, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727147.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27716, Q0KHV4, Q9W3T8
    UniProtKB/TrEMBL
    M9PGW0
    Related
    FBpp0070996
    Conserved Domains (1) summary
    pfam00876
    Location:20 → 351
    Innexin; Innexin

  6. NM_001272370.1 → NP_001259299.1  optic ganglion reduced, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259299.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27716, Q0KHV4, Q9W3T8
    UniProtKB/TrEMBL
    M9PGW0
    Conserved Domains (1) summary
    pfam00876
    Location:20 → 351
    Innexin; Innexin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGW0 M9PGW0
P27716.1 P27716

Gene LinkOut

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