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Aldh-III Aldehyde dehydrogenase type III [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45398, updated on 9-Dec-2024

Summary

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Official Symbol
Aldh-IIIprovided by FlyBase
Official Full Name
Aldehyde dehydrogenase type IIIprovided by FlyBase
Primary source
FLYBASE:FBgn0010548
Locus tag
Dmel_CG11140
See related
AllianceGenome:FB:FBgn0010548
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ALDH; ALDH-III; AldhIII; CG11140; CT41571; Dhap; Dmel\CG11140; FALDH; l(2)03610
Summary
Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in cellular aldehyde metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult brain; adult head; adult heart; epidermis; and gut section. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome and arteriosclerosis. Orthologous to several human genes including ALDH3B1 (aldehyde dehydrogenase 3 family member B1) and ALDH3B2 (aldehyde dehydrogenase 3 family member B2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Aldh-III in Genome Data Viewer
Location:
43C4-43C4; 2-56 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7466879..7477162, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3354384..3364667, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene p47 Neighboring gene wech Neighboring gene antisense RNA:CR43723 Neighboring gene Corepressor of Pangolin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A transposable element insertion confers xenobiotic resistance in Drosophila. Mateo L, et al. PLoS Genet, 2014 Aug. PMID 25122208, Free PMC Article
  2. Genetic mapping of the p47 (L.3.2) mutation in Drosophilamelanogaster. Cordes CN, et al. MicroPubl Biol, 2023. PMID 37799208, Free PMC Article
  3. Trade-off between toxicity and signal detection orchestrated by frequency- and density-dependent genes. Arthaud L, et al. PLoS One, 2011. PMID 21625551, Free PMC Article
  4. Proteomic analysis reveals oxidative stress-induced activation of Hippo signaling in thiamethoxam-exposed Drosophila. Li X, et al. Chemosphere, 2023 Oct. PMID 37437626
  5. Population genomics of transposable elements in Drosophila. Barrón MG, et al. Annu Rev Genet, 2014. PMID 25292358

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aldehyde metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aldehyde metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aldehyde metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
aldehyde dehydrogenase type III
Names
Aldh-III-PE
Aldh-III-PI
Aldh-III-PK
Aldh-III-PL
Aldh-III-PM
Aldh-III-PN
Aldh-III-PO
Aldh-III-PP
Aldh-III-PQ
Aldh-III-PR
Aldh-III-PS
Aldh-III-PU
CG11140-PE
CG11140-PI
CG11140-PK
CG11140-PL
CG11140-PM
CG11140-PN
CG11140-PO
CG11140-PP
CG11140-PQ
CG11140-PR
CG11140-PS
CG11140-PU
fatty aldehyde dehydrogenase
NP_001260772.1
NP_001260773.1
NP_001260775.1
NP_610285.5
NP_724560.1
NP_724561.2
NP_724562.2
NP_724563.2
NP_724564.2
NP_724565.3
NP_724566.3
NP_995772.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7466879..7477162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165531.3 → NP_724565.3  aldehyde dehydrogenase type III, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724565.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6Z4, Q8IGH3
    Conserved Domains (1) summary
    cd07132
    Location:71 → 514
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  2. NM_165528.3 → NP_724562.2  aldehyde dehydrogenase type III, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724562.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHC8, Q8IGH3
    Conserved Domains (1) summary
    cd07132
    Location:72 → 515
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  3. NM_165532.3 → NP_724566.3  aldehyde dehydrogenase type III, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724566.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZ69, E3CTS3
    Conserved Domains (1) summary
    cd07132
    Location:71 → 514
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  4. NM_136441.4 → NP_610285.5  aldehyde dehydrogenase type III, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610285.5

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4FEI5, E3CTS3, F0JAM9
    Conserved Domains (1) summary
    cd07132
    Location:72 → 515
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  5. NM_165529.3 → NP_724563.2  aldehyde dehydrogenase type III, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724563.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3CTS3, Q0E9G6, Q7JR61
    Conserved Domains (1) summary
    cd07132
    Location:6 → 449
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  6. NM_206050.3 → NP_995772.1  aldehyde dehydrogenase type III, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995772.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6Z3, Q8IGH3
    Conserved Domains (1) summary
    cd07132
    Location:6 → 449
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  7. NM_001273846.1 → NP_001260775.1  aldehyde dehydrogenase type III, isoform U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260775.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF99, Q8IGH3
    Conserved Domains (1) summary
    cd07132
    Location:6 → 449
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  8. NM_001273843.1 → NP_001260772.1  aldehyde dehydrogenase type III, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260772.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEE1, E3CTS3
    Conserved Domains (1) summary
    cd07132
    Location:6 → 449
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  9. NM_165527.3 → NP_724561.2  aldehyde dehydrogenase type III, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724561.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3CTS3, Q0E9G6, Q7JR61
    Conserved Domains (1) summary
    cd07132
    Location:6 → 449
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  10. NM_001273844.1 → NP_001260773.1  aldehyde dehydrogenase type III, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260773.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEL0, Q8IGH3
    Conserved Domains (1) summary
    cd07132
    Location:6 → 449
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  11. NM_165530.3 → NP_724564.2  aldehyde dehydrogenase type III, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724564.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3CTS3, Q0E9G6, Q7JR61
    Conserved Domains (1) summary
    cd07132
    Location:6 → 449
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  12. NM_165526.3 → NP_724560.1  aldehyde dehydrogenase type III, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724560.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3CTS3, Q0E9G6, Q7JR61
    Related
    FBpp0088066
    Conserved Domains (1) summary
    cd07132
    Location:6 → 449
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEE1 A0A0B4KEE1
A0A0B4KEL0 A0A0B4KEL0
A0A0B4KF99 A0A0B4KF99
A0A0C4DHC8 A0A0C4DHC8
A0A0C4FEI5 A0A0C4FEI5
A1Z6Z3 A1Z6Z3
A1Z6Z4 A1Z6Z4
A4UZ69 A4UZ69
Q7JR61 Q7JR61
Q8IGH3 Q8IGH3
Q8T0K8 Q8T0K8

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