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TrpRS Tryptophanyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45399, updated on 4-Jan-2025

Summary

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Official Symbol
TrpRSprovided by FlyBase
Official Full Name
Tryptophanyl-tRNA synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0010803
Locus tag
Dmel_CG9735
See related
AllianceGenome:FB:FBgn0010803
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
85D-WRS; Aats-trp; CG9735; Dmel\CG9735; dWARS; l(3)03559; l(3)03560; l(3)3559; wars; WRS; WRS-85D
Summary
Enables tryptophan-tRNA ligase activity. Involved in dendrite morphogenesis and tryptophanyl-tRNA aminoacylation. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval salivary gland; and organism. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See TrpRS in Genome Data Viewer
Location:
85D7-85D7; 3-48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9265027..9266904, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5090749..5092626, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting accessory protein 2 Neighboring gene salivary gland-expressed bHLH Neighboring gene Vacuolar protein sorting 16A Neighboring gene long non-coding RNA:CR46350

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in the predicted aspartyl tRNA synthetase of Drosophila are lethal and function as dosage-sensitive maternal modifiers of the sex determination gene Sex-lethal. Stitzinger SM, et al. Mol Gen Genet, 1999 Feb. PMID 10071220
  2. Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization. Chihara T, et al. Nat Neurosci, 2007 Jul. PMID 17529987
  3. Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis. Yeom E, et al. Front Cell Dev Biol, 2020. PMID 32117966, Free PMC Article
  4. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
  5. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tryptophan-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tryptophan-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tryptophanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tryptophanyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tryptophanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophanyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Tryptophanyl-tRNA synthetase
Names
CG9735-PB
TrpRS-PB
NP_524826.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9265027..9266904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080087.3 → NP_524826.1  Tryptophanyl-tRNA synthetase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524826.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI98, Q9U4Y1
    Related
    FBpp0081461
    Conserved Domains (2) summary
    PLN02486
    Location:45 → 426
    PLN02486; aminoacyl-tRNA ligase
    TIGR00233
    Location:115 → 422
    trpS; tryptophanyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KI98 Q0KI98
Q9U4Y0 Q9U4Y0
Q9U4Y1 Q9U4Y1

Gene LinkOut

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