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pgsA1 phosphatidylinositol phosphate synthase [ Mycobacterium canettii CIPT 140010059 ]

Gene ID: 45426615, updated on 11-Dec-2024

Summary

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Gene symbol
pgsA1
Gene description
phosphatidylinositol phosphate synthase
Locus tag
MCAN_RS13940
Gene type
protein coding
Organism
Mycobacterium canettii CIPT 140010059 (strain: CIPT 140010059)
Lineage
Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Old locus tag
MCAN_26551
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Genomic context

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Sequence:
NC_015848.1 (3009654..3010307, complement)

NC_015848.1Genomic Context describing neighboring genes Neighboring gene NUDIX domain-containing protein Neighboring gene phosphatidyl-myo-inositol alpha-mannosyltransferase Neighboring gene phosphatidylinositol mannoside acyltransferase Neighboring gene ATP adenylyltransferase Neighboring gene threonine--tRNA ligase Neighboring gene hypothetical protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_015848.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis. Grāve K, et al. Commun Biol, 2019. PMID 31098408, Free PMC Article
  2. Structural basis for phosphatidylinositol-phosphate biosynthesis. Clarke OB, et al. Nat Commun, 2015 Oct 16. PMID 26510127, Free PMC Article
  3. Studies of inositol 1-phosphate analogues as inhibitors of the phosphatidylinositol phosphate synthase in mycobacteria. Morii H, et al. J Biochem, 2013 Mar. PMID 23225597
  4. Phosphatidylinositol is an essential phospholipid of mycobacteria. Jackson M, et al. J Biol Chem, 2000 Sep 29. PMID 10889206
  5. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Supply P, et al. Nat Genet, 2013 Feb. PMID 23291586, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General protein information

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Preferred Names
phosphatidylinositol phosphate synthase
WP_014001353.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_015848.1 Reference assembly

    Range
    3009654..3010307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_014001353.1 phosphatidylinositol phosphate synthase [Mycobacterium canetti]

    See identical proteins and their annotated locations for WP_014001353.1

    UniProtKB/TrEMBL
    A0A8I0JX94
    Conserved Domains (1) summary
    COG0558
    Location:16 → 202
    PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
Nucleotide Protein
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