Pex1 Peroxin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pex1provided by FlyBase
Official Full Name: Peroxin 1provided by FlyBase
Primary source: FLYBASE:FBgn0013563
Locus tag: Dmel_CG6760
See related: AllianceGenome:FB:FBgn0013563
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0848/07; anon-WO0172774.100; anon-WO0172774.101; anon-WO0172774.102; anon-WO0172774.96; anon-WO0172774.98; anon-WO0172774.99; CG6760; DmCAB51031.1; DmelPex1; Dmel\CG6760; l(3)02402; l(3)084807; l(3)70Da; l(3)S084807; l(3)s4868; pex1; PEX1
Summary: Predicted to enable ATP hydrolysis activity; protein transporter activity; and ubiquitin-modified protein reader activity. Involved in nervous system development and peroxisome organization. Located in peroxisome. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Used to study Zellweger syndrome and peroxisome biogenesis disorder 14B. Human ortholog(s) of this gene implicated in Heimler syndrome 1; peroxisome biogenesis disorder 1A; and peroxisome biogenesis disorder 1B. Orthologous to human PEX1 (peroxisomal biogenesis factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 70D1-70D2; 3-42 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14071892..14076123)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14064992..14069223)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables protein transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-modified protein reader activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	IEA Inferred from Electronic Annotation more info
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein import into peroxisome matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into peroxisome matrix, receptor recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein unfolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein unfolding	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: peroxin 1

Names: CG6760-PA; Pex1-PA; lethal (3) 70Da

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

14071892..14076123

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143759.3 → NP_652016.1 peroxin 1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652016.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VUC7, Q9Y090

Related

FBpp0075519

Conserved Domains (4) summary

COG0464
Location:479 → 974

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

pfam00004
Location:757 → 887

AAA; ATPase family associated with various cellular activities (AAA)

pfam09262
Location:93 → 168

PEX-1N; Peroxisome biogenesis factor 1, N-terminal

cl21455
Location:480 → 604

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases