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Cyp4d14 Cytochrome P450 4d14 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45706, updated on 4-Jan-2025

Summary

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Official Symbol
Cyp4d14provided by FlyBase
Official Full Name
Cytochrome P450 4d14provided by FlyBase
Primary source
FLYBASE:FBgn0023541
Locus tag
Dmel_CG3540
See related
AllianceGenome:FB:FBgn0023541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4d14; CG3540; Cyp4D14; CYP4D14; Dmel\CG3540; EG:152A3.2
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic/larval midgut; and spermatozoon. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cyp4d14 in Genome Data Viewer
Location:
2E1-2E1; 1-0.8 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2173415..2175315, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2067448..2069348, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 4d1 Neighboring gene uncharacterized protein Neighboring gene mir-3641 stem loop Neighboring gene antisense RNA:CR45479 Neighboring gene NADH dehydrogenase (ubiquinone) B14.5 A subunit Neighboring gene antisense RNA:CR44690 Neighboring gene Cytochrome P450 4d2 Neighboring gene Cytochrome P450 4ae1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Vernì F, et al. Genetics, 2000 Apr. PMID 10747063, Free PMC Article
  2. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Beisswanger S, et al. Genetics, 2006 Jan. PMID 16204208, Free PMC Article
  3. Transcriptome analysis of Drosophila suzukii reveals molecular mechanisms conferring pyrethroid and spinosad resistance. Tabuloc CA, et al. Sci Rep, 2024 Aug 27. PMID 39191909, Free PMC Article
  4. Dietary Supplementation with Milk Lipids Leads to Suppression of Developmental and Behavioral Phenotypes of Hyperexcitable Drosophila Mutants. Kasuya J, et al. Neuroscience, 2023 Jun 1. PMID 37004908, Free PMC Article
  5. Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s. Nirusimhan V, et al. Curr Drug Metab, 2022. PMID 35546755

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4d14
Names
CG3540-PA
CG3540-PB
Cyp4d14-PA
Cyp4d14-PB
cytochrome P450
NP_001259179.1
NP_652020.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2173415..2175315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143763.4 → NP_652020.1  cytochrome P450 4d14, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652020.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46051
    UniProtKB/TrEMBL
    B6IDZ7
    Related
    FBpp0070410
    Conserved Domains (1) summary
    pfam00067
    Location:34 → 489
    p450; Cytochrome P450

  2. NM_001272250.2 → NP_001259179.1  cytochrome P450 4d14, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259179.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGI4
    Conserved Domains (1) summary
    pfam00067
    Location:34 → 489
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGI4 M9PGI4
O46051.1 O46051

Gene LinkOut

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