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mei-P26 meiotic P26 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45775, updated on 4-Jan-2025

Summary

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Official Symbol
mei-P26provided by FlyBase
Official Full Name
meiotic P26provided by FlyBase
Primary source
FLYBASE:FBgn0026206
Locus tag
Dmel_CG12218
See related
AllianceGenome:FB:FBgn0026206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AF145661; BcDNA:GH10646; CG12218; Dmel\CG12218; mei-p26; Mei-P26; MEI-P26; meiP26
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in germ cell development; meiotic cell cycle; and spermatogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in several structures, including germarium; germline cell; larval nervous system; ovary; and pole plasm. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin cancer. Orthologous to human PML (PML nuclear body scaffold). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See mei-P26 in Genome Data Viewer
Location:
8C15-8C17; 1-26 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9163255..9189309)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9057288..9083342)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Zpr1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in the beta-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brain. Arama E, et al. Oncogene, 2000 Aug 3. PMID 10949924
  2. Mei-P26 mediates tissue-specific responses to the Brat tumor suppressor and the dMyc proto-oncogene in Drosophila. Ferreira A, et al. Genetics, 2014 Sep. PMID 24990993, Free PMC Article
  3. A host parasite interaction rescues Drosophila oogenesis defects. Starr DJ, et al. Nature, 2002 Jul 4. PMID 12097909
  4. Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila. Chen D, et al. PLoS Genet, 2014 Nov. PMID 25412508, Free PMC Article
  5. Wolbachia endosymbionts manipulate the self-renewal and differentiation of germline stem cells to reinforce fertility of their fruit fly host. Russell SL, et al. PLoS Biol, 2023 Oct. PMID 37874788, Free PMC Article

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation.
    Title: Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation.
  2. Wh is a regulator of Mei-p26 in Drosophila germ cells
    Title: WD40 protein Wuho controls germline homeostasis via TRIM-NHL tumor suppressor Mei-p26 in Drosophila.
  3. Mei-P26 mediates tissue-specific responses to Brat and dMyc activities.
    Title: Mei-P26 mediates tissue-specific responses to the Brat tumor suppressor and the dMyc proto-oncogene in Drosophila.
  4. Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early germline stem cell development, suggesting that this protein helps to repress the translation of nanos mRNA.
    Title: Mei-p26 cooperates with Bam, Bgcn and Sxl to promote early germline development in the Drosophila ovary.
  5. Thus, germ cells progress through distinct, sequential regulatory states, from Mei-P26 on/Bam off to Bam on/Mei-P26 off.
    Title: A self-limiting switch based on translational control regulates the transition from proliferation to differentiation in an adult stem cell lineage.
  6. Mei-P26 has distinct functions in the ovary and participates in regulating the fates of both germline stem cells and their differentiating daughters.
    Title: Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling.
  7. miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing
    Title: The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing.
  8. Vas promotes germ cell differentiation by directly activating mei-P26 translation in early-stage committed cells
    Title: Vasa promotes Drosophila germline stem cell differentiation by activating mei-P26 translation by directly interacting with a (U)-rich motif in its 3' UTR.
  9. the Trim-NHL protein Mei-P26 restricts growth and proliferation in the ovarian stem cell lineage
    Title: Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in gamete generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
meiotic P26
Names
CG12218-PA
CG12218-PB
CG12218-PC
CG12218-PD
CG12218-PE
CG12218-PF
mei-P26-PA
mei-P26-PB
mei-P26-PC
mei-P26-PD
mei-P26-PE
mei-P26-PF
meiotic-P26

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9163255..9189309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272448.2 → NP_001259377.1  meiotic P26, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259377.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PH32, Q9Y111
    Conserved Domains (3) summary
    smart00502
    Location:369 → 494
    BBC; B-Box C-terminal domain
    cd00021
    Location:321 → 360
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd14959
    Location:930 → 1203
    NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins

  2. NM_001369966.1 → NP_001356936.1  meiotic P26, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4D6K5H4, Q9Y111
    Conserved Domains (4) summary
    smart00502
    Location:369 → 494
    BBC; B-Box C-terminal domain
    cd00021
    Location:321 → 360
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd14959
    Location:913 → 1186
    NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
    cl17238
    Location:158 → 230
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. NM_143765.4 → NP_652022.1  meiotic P26, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652022.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W378, Q9Y111
    Related
    FBpp0071238
    Conserved Domains (3) summary
    smart00502
    Location:369 → 494
    BBC; B-Box C-terminal domain
    cd00021
    Location:321 → 360
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd14959
    Location:913 → 1186
    NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins

  4. NM_001272449.1 → NP_001259378.1  meiotic P26, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259378.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W378, Q9Y111
    Conserved Domains (3) summary
    smart00502
    Location:369 → 494
    BBC; B-Box C-terminal domain
    cd00021
    Location:321 → 360
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd14959
    Location:913 → 1186
    NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins

  5. NM_001272447.2 → NP_001259376.1  meiotic P26, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259376.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W378, Q9Y111
    Conserved Domains (3) summary
    smart00502
    Location:369 → 494
    BBC; B-Box C-terminal domain
    cd00021
    Location:321 → 360
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd14959
    Location:913 → 1186
    NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins

  6. NM_001298110.1 → NP_001285039.1  meiotic P26, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285039.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PH32, Q9Y111
    Conserved Domains (3) summary
    smart00502
    Location:369 → 494
    BBC; B-Box C-terminal domain
    cd00021
    Location:321 → 360
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd14959
    Location:930 → 1203
    NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A4D6K5H4 A0A4D6K5H4
M9PH32 M9PH32
Q9W378 Q9W378
Q9Y111 Q9Y111

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