Hex-A Hexokinase A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hex-Aprovided by FlyBase
Official Full Name: Hexokinase Aprovided by FlyBase
Primary source: FLYBASE:FBgn0001186
Locus tag: Dmel_CG3001
See related: AllianceGenome:FB:FBgn0001186
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: B; CG3001; DM1; Dmel\CG3001; Hex; HEX; HEX-A; Hex-A:B; HexA; hexokinase; HK; HK-A
Summary: Enables glucosamine kinase activity and hexokinase activity. Involved in canonical glycolysis and glucose 6-phosphate metabolic process. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; dorsal ectoderm; dorsal epidermis primordium; and embryonic epipharynx. Used to study glucose metabolism disease. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 4G; anemia (multiple); artery disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including GCK (glucokinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 8E10-8E10; 1-28 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (9585675..9589813)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (9479708..9483846)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2.
Title: Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2.
An analysis of the elements regulating the expression of Hex-A is reported.
Title: Functional analysis of Drosophila melanogaster hexokinase Hex-A locus: multiple Initiator-like elements enhance DPE containing promoter activity.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables D-glucose binding	IEA Inferred from Electronic Annotation more info
enables fructokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucokinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glucosamine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables hexokinase activity	IEA Inferred from Electronic Annotation more info
enables hexokinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mannokinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical glycolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose 6-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular glucose homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hexokinase A

Names: CG3001-PA; CG3001-PB; CG3001-PC; Hex-A-PA; Hex-A-PB; Hex-A-PC; hexokinase; hexokinase-A; muscle-specific hexokinase

NP_001259384.1

EC 2.7.1.-

EC 2.7.1.1

EC 2.7.1.2

EC 2.7.1.4

NP_524848.1

EC 2.7.1.-

EC 2.7.1.1

EC 2.7.1.2

EC 2.7.1.4

NP_727350.1

EC 2.7.1.-

EC 2.7.1.1

EC 2.7.1.2

EC 2.7.1.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

9585675..9589813

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272455.2 → NP_001259384.1 hexokinase A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259384.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9GNH8

Conserved Domains (3) summary

COG5026
Location:2 → 438

COG5026; Hexokinase [Carbohydrate transport and metabolism]

pfam00349
Location:2 → 197

Hexokinase_1; Hexokinase

pfam03727
Location:203 → 437

Hexokinase_2; Hexokinase
NM_080109.4 → NP_524848.1 hexokinase A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524848.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W330

Related

FBpp0071296

Conserved Domains (2) summary

pfam00349
Location:95 → 290

Hexokinase_1

pfam03727
Location:296 → 530

Hexokinase_2
NM_167194.3 → NP_727350.1 hexokinase A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727350.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9GNH8

Related

FBpp0071297

Conserved Domains (3) summary

COG5026
Location:2 → 438

COG5026; Hexokinase [Carbohydrate transport and metabolism]

pfam00349
Location:2 → 197

Hexokinase_1; Hexokinase

pfam03727
Location:203 → 437

Hexokinase_2; Hexokinase