fs(1)N female sterile (1) Nasrat [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fs(1)Nprovided by FlyBase
Official Full Name: female sterile (1) Nasratprovided by FlyBase
Primary source: FLYBASE:FBgn0004650
Locus tag: Dmel_CG11411
See related: AllianceGenome:FB:FBgn0004650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 371; 8D8.1; CG11411; Dmel\CG11411; EG:8D8.1; fs(1)A371; fs(1)K1540; fs(1)M6; Fs(1)N; fs(1)Nas; fs(1)Nasrat; fs(1)[nas]; nas; Nas
Summary: Predicted to enable heparin binding activity. Involved in terminal region determination; torso signaling pathway; and vitelline membrane formation involved in chorion-containing eggshell formation. Located in external side of plasma membrane and vitelline envelope. Is expressed in organism. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (1322513..1329438)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1216546..1223471)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

move from the oocyte to the follicle cells in process that does not require endocytosis
Title: Germline and somatic vitelline proteins colocalize in aggregates in the follicular epithelium of Drosophila ovaries.
closca is a gene encoding a new member of a group of proteins that act non-redundantly in vitelline membrane biogenesis and in Torso signalling; Nasrat protein is another member of this group incorporated into the vitelline membrane
Title: closca, a new gene required for both Torso RTK activation and vitelline membrane integrity. Germline proteins contribute to Drosophila eggshell composition.
Nasrat and Polehole are essential for extracellular accumulation of Torso-like, a factor secreted during oogenesis that initiates Torso receptor activation
Title: Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis.
Required for cross-linkage of the vitelline membrane.
Title: Drosophila vitelline membrane cross-linking requires the fs(1)Nasrat, fs(1)polehole and chorion genes activities.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chorion-containing eggshell formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in chorion-containing eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal region determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in torso signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitelline membrane formation involved in chorion-containing eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vitelline envelope	IDA Inferred from Direct Assay more info	PubMed