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Ccs Copper chaperone for superoxide dismutase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46035, updated on 4-Jan-2025

Summary

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Official Symbol
Ccsprovided by FlyBase
Official Full Name
Copper chaperone for superoxide dismutaseprovided by FlyBase
Primary source
FLYBASE:FBgn0010531
Locus tag
Dmel_CG17753
See related
AllianceGenome:FB:FBgn0010531
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey231; CCD; CCS; CG-17753; CG17753; dCCS; DmCCS; Dmel\CG17753; l(2)03221
Summary
Enables superoxide dismutase copper chaperone activity. Involved in determination of adult lifespan; protein stabilization; and response to oxidative stress. Located in peroxisome. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human CCS (copper chaperone for superoxide dismutase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ccs in Genome Data Viewer
Location:
46F1-46F1; 2-62 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10121486..10122574, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6008991..6010079, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphofructokinase Neighboring gene dampened Neighboring gene uncharacterized protein Neighboring gene gemini Neighboring gene antisense RNA:CR43467 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 46a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeting of copper-trafficking chaperones causes gene-specific systemic pathology in Drosophila melanogaster: prospective expansion of mutational landscapes that regulate tumor resistance to cisplatin. Theotoki EI, et al. Biol Open, 2019 Oct 15. PMID 31575544, Free PMC Article
  2. DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster. De Lazzari F, et al. Antioxidants (Basel), 2022 Aug 5. PMID 36009245, Free PMC Article
  3. Essential roles in development and pigmentation for the Drosophila copper transporter DmATP7. Norgate M, et al. Mol Biol Cell, 2006 Jan. PMID 16251357, Free PMC Article
  4. Superoxide dismutase evolution and life span regulation. Landis GN, et al. Mech Ageing Dev, 2005 Mar. PMID 15664623
  5. What can flies tell us about copper homeostasis? Southon A, et al. Metallomics, 2013 Oct. PMID 23903872

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables superoxide dismutase copper chaperone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables superoxide dismutase copper chaperone activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
copper chaperone for superoxide dismutase
Names
CCS
CG17753-PB
CG17753-PC
Ccs-PB
Ccs-PC
Cu-chaperone for superoxide dismutase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10121486..10122574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143772.5 → NP_652029.3  copper chaperone for superoxide dismutase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652029.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z850, Q9BLY4
    Conserved Domains (2) summary
    cd00305
    Location:66 → 217
    Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...
    cd00371
    Location:6 → 58
    HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

  2. NM_001169637.3 → NP_001163108.1  copper chaperone for superoxide dismutase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163108.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JH26, Q9BLY4
    Conserved Domains (3) summary
    PLN02957
    Location:1 → 253
    PLN02957; copper, zinc superoxide dismutase
    cd00305
    Location:72 → 223
    Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...
    cd00371
    Location:5 → 64
    HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z850 A1Z850
E1JH26 E1JH26
Q9BLY4 Q9BLY4

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