Sply Sphingosine-1-phosphate lyase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Splyprovided by FlyBase
Official Full Name: Sphingosine-1-phosphate lyaseprovided by FlyBase
Primary source: FLYBASE:FBgn0010591
Locus tag: Dmel_CG8946
See related: AllianceGenome:FB:FBgn0010591
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0142479.5; CG8946; Dmel\CG8946; l(2)05091; spl; Spl; SPL; sply
Summary: Enables sphinganine-1-phosphate aldolase activity. Involved in adult somatic muscle development and sphingolipid catabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; extraembryonic structure; gut section; and visceral mesoderm derivative. Used to study Charcot-Marie-Tooth disease; nephrotic syndrome; and obesity. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 53F6-53F7; 2-81 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (17088441..17091958, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12975946..12979463, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In Drosophila, Sply mutants, which lack SGPL1, displayed a phenotype reminiscent of nephrotic syndrome in nephrocytes.
Title: Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.
There are defects in reproductive structures and function that are associated with enhanced apoptosis in Drosophila Sply05091 mutants that lack functional S1P lyase and thereby accumulate sphingolipid long chain base metabolites.
Title: Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila.
cloning of the sphingosine-1-phosphate lyase gene (Sply) and its importance for adult muscle development and integrity, reproduction and larval viability
Title: Sply regulation of sphingolipid signaling molecules is essential for Drosophila development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables sphinganine-1-phosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphinganine-1-phosphate aldolase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adult somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: Sphingosine-1-phosphate lyase

Names: CG8946-PA; CG8946-PB; Sply-PA; Sply-PB; sphinganine-1-phosphate lyase; sphingosine-1-phosphate lyase

NP_652032.1

EC 4.1.-.-

EC 4.1.2.27

NP_725652.1

EC 4.1.-.-

EC 4.1.2.27

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

17088441..17091958 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143775.3 → NP_652032.1 Sphingosine-1-phosphate lyase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652032.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0E946, Q9V7Y2

Related

FBpp0086158

Conserved Domains (1) summary

cd06450
Location:132 → 494

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
NM_166215.2 → NP_725652.1 Sphingosine-1-phosphate lyase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725652.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0E946, Q9V7Y2

Related

FBpp0086159

Conserved Domains (1) summary

cd06450
Location:132 → 494

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...