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Sec61beta Sec61 beta subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46080, updated on 9-Dec-2024

Summary

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Official Symbol
Sec61betaprovided by FlyBase
Official Full Name
Sec61 beta subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0010638
Locus tag
Dmel_CG10130
See related
AllianceGenome:FB:FBgn0010638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10130; Dmel\CG10130; dSec61beta; DSec61beta; l(2)07214; Sec1; Sec61; sec61b; Sec61b; Sec61B; sec61beta; Secbeta61
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in negative regulation of autophagy. Located in endomembrane system. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; epidermis; gut section; and mesoderm. Orthologous to human SEC61B (SEC61 translocon subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Sec61beta in Genome Data Viewer
Location:
51B6-51B6; 2-72 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14618771..14619681)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10506276..10507186)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Su(var)2-HP2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene U snoRNA host gene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rapid subcellular calcium responses and dynamics by calcium sensor G-CatchER(). Reddish FN, et al. iScience, 2021 Mar 19. PMID 33665552, Free PMC Article
  2. Membrane Asymmetry Imposes Directionality on Lipid Droplet Emergence from the ER. Chorlay A, et al. Dev Cell, 2019 Jul 1. PMID 31155466
  3. Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development. Valcárcel R, et al. J Cell Sci, 1999 Dec. PMID 10564656
  4. The effects of ER morphology on synaptic structure and function in Drosophila melanogaster. Summerville JB, et al. J Cell Sci, 2016 Apr 15. PMID 26906425, Free PMC Article
  5. The Drosophila Nesprin-1 homolog MSP300 is required for muscle autophagy and proteostasis. van der Graaf K, et al. J Cell Sci, 2024 Jun 1. PMID 38757366, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Sec61 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Sec61 translocon complex IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sec61 beta subunit
Names
CG10130-PA
Sec61beta-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14618771..14619681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143780.4 → NP_652037.1  Sec61 beta subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652037.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JZN0
    Related
    FBpp0086627
    Conserved Domains (1) summary
    pfam03911
    Location:58 → 95
    Sec61_beta; Sec61beta family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JZN0 Q7JZN0
Q8SXW0 Q8SXW0

Gene LinkOut

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