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sinu sinuous [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46187, updated on 9-Dec-2024

Summary

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Official Symbol
sinuprovided by FlyBase
Official Full Name
sinuousprovided by FlyBase
Primary source
FLYBASE:FBgn0010894
Locus tag
Dmel_CG10624
See related
AllianceGenome:FB:FBgn0010894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6524; CG10624; Dmel\CG10624; i8; l(3)06524; Sinu
Summary
Involved in several processes, including cell adhesion involved in heart morphogenesis; establishment of glial blood-brain barrier; and septate junction assembly. Located in plasma membrane and septate junction. Is expressed in several structures, including adult head; dorsal epidermis primordium; embryonic dorsal epidermis; embryonic head epidermis; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See sinu in Genome Data Viewer
Location:
64D3-64D3; 3-14 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5559470..5561598, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5552570..5554698, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene farmer Neighboring gene Succinyl-coenzyme A synthetase beta subunit, GDP-forming Neighboring gene severas

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Triple-Repeat Protein Anakonda Controls Epithelial Tricellular Junction Formation in Drosophila. Byri S, et al. Dev Cell, 2015 Jun 8. PMID 25982676
  2. Epidermal impermeable barriers in mouse and fly. Jane SM, et al. Curr Opin Genet Dev, 2005 Aug. PMID 15950458
  3. A UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is required for epithelial tube formation. Tian E, et al. J Biol Chem, 2007 Jan 5. PMID 17098739
  4. Septate junction proteins are required for egg elongation and border cell migration during oogenesis in Drosophila. Alhadyian H, et al. G3 (Bethesda), 2021 Jul 14. PMID 33871584, Free PMC Article
  5. The bicistronic gene würmchen encodes two essential components for epithelial development in Drosophila. Königsmann T, et al. Dev Biol, 2020 Jul 1. PMID 32361005

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Encodes a claudin that localizes to septate junctions and is required for septate junction organization and paracellular barrier function. (Sinuous)
    Title: Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cell adhesion involved in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of glial blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heart process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube size, open tracheal system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of tube size, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septate junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in septate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in septate junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in septate junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sinuous
Names
CG10624-PA
sinu-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5559470..5561598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139714.4 → NP_647971.3  sinuous [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647971.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6TDU6, Q8T047, Q9VRM3
    Conserved Domains (1) summary
    pfam13903
    Location:44 → 223
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VRM3 Q9VRM3

Gene LinkOut

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