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PTTG1 PTTG1 regulator of sister chromatid separation, securin [ Pan troglodytes (chimpanzee) ]

Gene ID: 462238, updated on 17-Aug-2024

Summary

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Official Symbol
PTTG1provided by VGNC
Official Full Name
PTTG1 regulator of sister chromatid separation, securinprovided by VGNC
Primary source
VGNC:VGNC:59223
Locus tag
CK820_G0010250
See related
Ensembl:ENSPTRG00000017492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Also known as
Securin
Orthologs
human mouse all
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Genomic context

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See PTTG1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 4 NC_072402.2 (158115121..158121930)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 5 NC_072403.1 (158134699..158141508)

Chromosome 4 - NC_072402.2Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 200 member C Neighboring gene SLU7 homolog, splicing factor Neighboring gene uncharacterized LOC129144113 Neighboring gene microRNA mir-146a Neighboring gene ATPase phospholipid transporting 10B (putative)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An empirical test for branch-specific positive selection. Nickel GC, et al. Genetics, 2008 Aug. PMID 18689901, Free PMC Article
  2. Selection on human genes as revealed by comparisons to chimpanzee cDNA. Hellmann I, et al. Genome Res, 2003 May. PMID 12727903, Free PMC Article
  3. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in homologous chromosome segregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
securin
Names
pituitary tumor-transforming 1
pituitary tumor-transforming gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135616.2 → NP_001129088.2  securin

    See identical proteins and their annotated locations for NP_001129088.2

    Status: VALIDATED

    Source sequence(s)
    CB297210, JAQQLN020000004
    UniProtKB/Swiss-Prot
    A2T767
    UniProtKB/TrEMBL
    A0A2J8NKG4, A0A6D2WKU7, G2HDW5, H2QRY0
    Related
    ENSPTRP00000029883.4, ENSPTRT00000032342.5
    Conserved Domains (1) summary
    pfam04856
    Location:1 → 191
    Securin; Securin sister-chromatid separation inhibitor

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072402.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    158115121..158121930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009450039.4 → XP_009448314.1  securin isoform X1

    See identical proteins and their annotated locations for XP_009448314.1

    UniProtKB/Swiss-Prot
    A2T767
    UniProtKB/TrEMBL
    A0A2J8NKG4, A0A6D2WKU7, G2HDW5, H2QRY0
    Conserved Domains (1) summary
    pfam04856
    Location:1 → 191
    Securin; Securin sister-chromatid separation inhibitor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2T767.1 GenPept UniProtKB/Swiss-Prot:A2T767

Gene LinkOut

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Molecular Biology Databases
Research Materials