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MYLK myosin light chain kinase [ Homo sapiens (human) ]

Gene ID: 4638, updated on 27-Nov-2024

Summary

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Official Symbol
MYLKprovided by HGNC
Official Full Name
myosin light chain kinaseprovided by HGNC
Primary source
HGNC:HGNC:7590
See related
Ensembl:ENSG00000065534 MIM:600922; AllianceGenome:HGNC:7590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KRP; AAT7; MLCK; MLCK1; MMIHS; MYLK1; MMIHS1; MYLK-L; smMLCK; MLCK108; MLCK210; MSTP083
Summary
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
Expression
Broad expression in prostate (RPKM 187.5), endometrium (RPKM 154.5) and 18 other tissues See more
Orthologs
mouse all
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Genomic context

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See MYLK in Genome Data Viewer
Location:
3q21.1
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (123610049..123884332, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (126330173..126610461, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (123328896..123603179, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123104604-123105104 Neighboring gene uncharacterized LOC124909420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123105105-123105605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123130683-123131208 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:123132020-123132563 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:123166099-123166998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123178428-123178928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123178929-123179429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14647 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20393 Neighboring gene MPRA-validated peak4801 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20394 Neighboring gene MYLK antisense RNA 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:123347871-123349070 Neighboring gene Sharpr-MPRA regulatory region 9008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123354794-123355455 Neighboring gene uncharacterized LOC124909421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123368429-123368930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123368931-123369430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123372559-123373059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123401333-123402150 Neighboring gene uncharacterized LOC105369194 Neighboring gene MYLK antisense RNA 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:123511339-123512538 Neighboring gene Sharpr-MPRA regulatory region 10510 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene MPRA-validated peak4802 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14650 Neighboring gene coiled-coil domain containing 14 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:123680084-123680394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123699087-123699586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:123710743-123711259 Neighboring gene rhophilin associated tail protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome. Szilágyi KL, et al. Transl Res, 2017 Feb. PMID 27543902, Free PMC Article
  2. Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants. Shen K, et al. PLoS One, 2015. PMID 26111161, Free PMC Article
  3. A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans. Flores C, et al. Genet Epidemiol, 2007 May. PMID 17266121
  4. Role of myosin light chain and myosin light chain kinase in advanced glycation end product-induced endothelial hyperpermeability in vitro and in vivo. Wu F, et al. Diab Vasc Dis Res, 2016 Mar. PMID 26607798
  5. Myosin light chain kinase plays a role in the regulation of epithelial cell survival. Connell LE, et al. J Cell Sci, 2006 Jun 1. PMID 16723733

See all (175) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of myosin light chain kinase induces the cellular senescence associated secretory phenotype to promote breast epithelial cell migration.
    Title: Loss of myosin light chain kinase induces the cellular senescence associated secretory phenotype to promote breast epithelial cell migration.
  2. The SNHG12/microRNA-15b-5p/MYLK axis regulates vascular smooth muscle cell phenotype to affect intracranial aneurysm formation.
    Title: The SNHG12/microRNA-15b-5p/MYLK axis regulates vascular smooth muscle cell phenotype to affect intracranial aneurysm formation.
  3. Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease.
    Title: Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease.
  4. The m(6)A methyltransferase METTL3 promotes trophoblast cell invasion by regulating MYLK expression.
    Title: The m(6)A methyltransferase METTL3 promotes trophoblast cell invasion by regulating MYLK expression.
  5. SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK.
    Title: SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK.
  6. CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a.
    Title: CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a.
  7. Procyanidin A1 and its digestive products prevent acrylamide-induced intestinal barrier dysfunction via the MAPK-mediated MLCK pathway.
    Title: Procyanidin A(1) and its digestive products prevent acrylamide-induced intestinal barrier dysfunction via the MAPK-mediated MLCK pathway.
  8. Myosin light chain kinase-driven myosin II turnover regulates actin cortex contractility during mitosis.
    Title: Myosin light chain kinase-driven myosin II turnover regulates actin cortex contractility during mitosis.
  9. CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.
    Title: CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.
  10. A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis.
    Title: A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis.
Submit: New GeneRIF Correction See all GeneRIFs (99)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in MYLK that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2016-01-14)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2016-01-14)

ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat in combination with morphine activates myosin light chain kinase expression in primary brain micro vascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12216, DKFZp686I10125

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin light chain kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin light chain kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in aorta smooth muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bleb assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular hypotonic response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of wound healing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tonic smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tonic smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin light chain kinase, smooth muscle
Names
kinase-related protein
myosin, light polypeptide kinase
smooth muscle myosin light chain kinase
telokin
NP_001308238.1
NP_444253.3
NP_444254.3
NP_444255.3
NP_444256.3
NP_444259.1
NP_444260.1
XP_011511162.2
XP_011511163.2
XP_016861958.2
XP_016861959.1
XP_016861960.1
XP_016861961.1
XP_016861962.1
XP_024309300.1
XP_024309302.1
XP_024309305.1
XP_047304138.1
XP_047304139.1
XP_047304140.1
XP_047304141.1
XP_047304142.1
XP_047304143.1
XP_047304144.1
XP_054202587.1
XP_054202588.1
XP_054202589.1
XP_054202590.1
XP_054202591.1
XP_054202592.1
XP_054202593.1
XP_054202594.1
XP_054202595.1
XP_054202596.1
XP_054202597.1
XP_054202598.1
XP_054202599.1
XP_054202600.1
XP_054202601.1
XP_054202602.1
XP_054202603.1
XP_054202604.1
XP_054202605.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029111.2 RefSeqGene

    Range
    5000..279283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321309.2 → NP_001308238.1  myosin light chain kinase, smooth muscle isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC020634, AC023165, AC117381, AY339601, BC064695, BC113458, BQ006428, DA853780, U48959
    UniProtKB/TrEMBL
    A0A8I5QKL9
    Conserved Domains (9) summary
    cd00096
    Location:464 → 533
    Ig; Immunoglobulin domain
    cd05762
    Location:1062 → 1159
    Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
    smart00408
    Location:1646 → 1713
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:1155 → 1247
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1633 → 1723
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:1285 → 1543
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam00069
    Location:1288 → 1543
    Pkinase; Protein kinase domain
    pfam16620
    Location:75 → 236
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:548 → 633
    Ig; Immunoglobulin domain

  2. NM_053025.4 → NP_444253.3  myosin light chain kinase, smooth muscle isoform 1

    See identical proteins and their annotated locations for NP_444253.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the full-length transcript and encodes the full-length nonmuscle isoform.
    Source sequence(s)
    AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
    Consensus CDS
    CCDS46896.1
    UniProtKB/Swiss-Prot
    B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q15746, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9
    UniProtKB/TrEMBL
    A0A8I5QKL9
    Related
    ENSP00000353452.3, ENST00000360304.8
    Conserved Domains (5) summary
    cd05762
    Location:1238 → 1335
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:1331 → 1423
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1809 → 1899
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:1461 → 1719
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:251 → 412
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

  3. NM_053026.4 → NP_444254.3  myosin light chain kinase, smooth muscle isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) does not utilize exon 11, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
    Consensus CDS
    CCDS43141.1
    UniProtKB/TrEMBL
    A0A8I5QKL9
    Related
    ENSP00000510503.1, ENST00000693689.1
    Conserved Domains (5) summary
    cd05762
    Location:1169 → 1266
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:1262 → 1354
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1740 → 1830
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:1392 → 1650
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:251 → 412
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

  4. NM_053027.4 → NP_444255.3  myosin light chain kinase, smooth muscle isoform 3A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3A) does not utilize exon 30, compared to variant 1, resulting in a shorter protein (isoform 3A), compared to isoform 1.
    Source sequence(s)
    AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
    Consensus CDS
    CCDS3023.1
    UniProtKB/TrEMBL
    A0A8I5QKL9
    Related
    ENSP00000354004.3, ENST00000360772.7
    Conserved Domains (9) summary
    cd00096
    Location:640 → 709
    Ig; Immunoglobulin domain
    cd05762
    Location:1238 → 1335
    Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
    smart00408
    Location:1771 → 1838
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:1331 → 1423
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1758 → 1848
    I-set; Immunoglobulin I-set domain
    pfam00069
    Location:1464 → 1668
    Pkinase; Protein kinase domain
    pfam16620
    Location:251 → 412
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:724 → 809
    Ig; Immunoglobulin domain
    cl21453
    Location:1461 → 1668
    PKc_like; Protein Kinases, catalytic domain

  5. NM_053028.4 → NP_444256.3  myosin light chain kinase, smooth muscle isoform 3B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3B) does not utilize exons 11 and 30, compared to variant 1, resulting in a shorter protein (isoform 3B), compared to isoform 1.
    Source sequence(s)
    AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
    Consensus CDS
    CCDS93356.1
    UniProtKB/TrEMBL
    A0A8I5QKL9
    Related
    ENSP00000320622.6, ENST00000346322.10
    Conserved Domains (9) summary
    cd00096
    Location:571 → 640
    Ig; Immunoglobulin domain
    cd05762
    Location:1169 → 1266
    Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
    smart00408
    Location:1702 → 1769
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:1262 → 1354
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1689 → 1779
    I-set; Immunoglobulin I-set domain
    pfam00069
    Location:1395 → 1599
    Pkinase; Protein kinase domain
    pfam16620
    Location:251 → 412
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:655 → 740
    Ig; Immunoglobulin domain
    cl21453
    Location:1392 → 1599
    PKc_like; Protein Kinases, catalytic domain

  6. NM_053031.4 → NP_444259.1  myosin light chain kinase, smooth muscle isoform 7

    See identical proteins and their annotated locations for NP_444259.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes the shorter isoform of kinase related protein, telokin. The first exon corresponds to intron 30 and the remainder of the transcript corresponds to the last two exons of the gene. It is shorter than variant 8 by one codon at the splicing junction between the first two exons.
    Source sequence(s)
    AC023165, BC064420, BC113458, DB016380
    Consensus CDS
    CCDS58849.1
    UniProtKB/TrEMBL
    Q05B97
    Related
    ENSP00000510047.1, ENST00000685744.1
    Conserved Domains (1) summary
    cd20973
    Location:51 → 138
    IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

  7. NM_053032.4 → NP_444260.1  myosin light chain kinase, smooth muscle isoform 8

    See identical proteins and their annotated locations for NP_444260.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) encodes the longer isoform of kinase related protein, telokin. It is longer than variant 7 by one codon at the splicing junction between the first two exons.
    Source sequence(s)
    AC023165, BC064420, BC113456, DB016380
    Consensus CDS
    CCDS46897.1
    UniProtKB/TrEMBL
    Q05B97
    Related
    ENSP00000428967.1, ENST00000418370.6
    Conserved Domains (1) summary
    cd20973
    Location:52 → 139
    IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    123610049..123884332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448184.1 → XP_047304140.1  myosin light chain kinase, smooth muscle isoform X7

    UniProtKB/Swiss-Prot
    B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q15746, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9

  2. XM_024453532.2 → XP_024309300.1  myosin light chain kinase, smooth muscle isoform X6

    UniProtKB/TrEMBL
    A0A8I5KU53, A0A8I5QKL9
    Related
    ENSP00000508761.1, ENST00000687848.1
    Conserved Domains (5) summary
    cd05762
    Location:1248 → 1345
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:1341 → 1433
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1819 → 1909
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:1471 → 1729
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:261 → 422
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

  3. XM_047448183.1 → XP_047304139.1  myosin light chain kinase, smooth muscle isoform X6

    UniProtKB/TrEMBL
    A0A8I5KU53

  4. XM_047448187.1 → XP_047304143.1  myosin light chain kinase, smooth muscle isoform X6

    UniProtKB/TrEMBL
    A0A8I5KU53

  5. XM_047448186.1 → XP_047304142.1  myosin light chain kinase, smooth muscle isoform X8

  6. XM_017006469.3 → XP_016861958.2  myosin light chain kinase, smooth muscle isoform X5

  7. XM_024453534.2 → XP_024309302.1  myosin light chain kinase, smooth muscle isoform X3

    UniProtKB/TrEMBL
    A0A8I5QKL9
    Related
    ENSP00000508777.1, ENST00000690457.1
    Conserved Domains (5) summary
    cd05762
    Location:1179 → 1276
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:1272 → 1364
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1750 → 1840
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:1402 → 1660
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:261 → 422
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

  8. XM_047448182.1 → XP_047304138.1  myosin light chain kinase, smooth muscle isoform X4

  9. XM_011512861.4 → XP_011511163.2  myosin light chain kinase, smooth muscle isoform X2

    UniProtKB/TrEMBL
    A0A8I5QKL9
    Conserved Domains (5) summary
    cd05762
    Location:1248 → 1345
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:1341 → 1433
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1751 → 1841
    I-set; Immunoglobulin I-set domain
    pfam16620
    Location:261 → 422
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl21453
    Location:1483 → 1661
    PKc_like; Protein Kinases, catalytic domain

  10. XM_011512860.4 → XP_011511162.2  myosin light chain kinase, smooth muscle isoform X1

    UniProtKB/TrEMBL
    A0A8I5QKL9
    Conserved Domains (5) summary
    cd05762
    Location:1248 → 1345
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:1341 → 1433
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1818 → 1908
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:1471 → 1729
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:261 → 422
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

  11. XM_024453537.2 → XP_024309305.1  myosin light chain kinase, smooth muscle isoform X7

    UniProtKB/Swiss-Prot
    B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q15746, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9
    UniProtKB/TrEMBL
    A0A8I5QKL9
    Related
    ENSP00000508758.1, ENST00000686761.1
    Conserved Domains (5) summary
    cd05762
    Location:1238 → 1335
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:1331 → 1423
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1809 → 1899
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:1461 → 1719
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:251 → 412
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

  12. XM_047448185.1 → XP_047304141.1  myosin light chain kinase, smooth muscle isoform X7

    UniProtKB/Swiss-Prot
    B4DUE3, D3DN97, O95796, O95797, O95798, O95799, Q14844, Q15746, Q16794, Q17S15, Q3ZCP9, Q5MY99, Q5MYA0, Q6P2N0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UBY6, Q9UIT9

  13. XM_047448188.1 → XP_047304144.1  myosin light chain kinase, smooth muscle isoform X11

  14. XM_017006470.3 → XP_016861959.1  myosin light chain kinase, smooth muscle isoform X10

    UniProtKB/TrEMBL
    A0A8I5KTQ1
    Related
    ENSP00000510593.1, ENST00000685953.1

  15. XM_017006471.3 → XP_016861960.1  myosin light chain kinase, smooth muscle isoform X9

    UniProtKB/Swiss-Prot
    Q15746
    Related
    ENSP00000422984.2, ENST00000508240.2
    Conserved Domains (4) summary
    cd00063
    Location:131 → 223
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05762
    Location:37 → 135
    IgI_8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar protein; member of the I-set of IgSF domains
    cd20973
    Location:612 → 699
    IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains
    cl21453
    Location:261 → 519
    PKc_like; Protein Kinases, catalytic domain

  16. XM_017006473.2 → XP_016861962.1  myosin light chain kinase, smooth muscle isoform X13

    UniProtKB/TrEMBL
    Q05B97
    Related
    ENSP00000509867.1, ENST00000687375.1
    Conserved Domains (1) summary
    cd20973
    Location:51 → 138
    IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

  17. XM_017006472.3 → XP_016861961.1  myosin light chain kinase, smooth muscle isoform X12

    UniProtKB/TrEMBL
    Q05B97
    Related
    ENSP00000462118.1, ENST00000583087.6
    Conserved Domains (1) summary
    cd20973
    Location:52 → 139
    IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    126330173..126610461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346621.1 → XP_054202596.1  myosin light chain kinase, smooth muscle isoform X7

  2. XM_054346619.1 → XP_054202594.1  myosin light chain kinase, smooth muscle isoform X6

  3. XM_054346625.1 → XP_054202600.1  myosin light chain kinase, smooth muscle isoform X6

  4. XM_054346616.1 → XP_054202591.1  myosin light chain kinase, smooth muscle isoform X4

  5. XM_054346614.1 → XP_054202589.1  myosin light chain kinase, smooth muscle isoform X2

  6. XM_054346612.1 → XP_054202587.1  myosin light chain kinase, smooth muscle isoform X1

  7. XM_054346624.1 → XP_054202599.1  myosin light chain kinase, smooth muscle isoform X8

  8. XM_054346617.1 → XP_054202592.1  myosin light chain kinase, smooth muscle isoform X5

  9. XM_054346613.1 → XP_054202588.1  myosin light chain kinase, smooth muscle isoform X7

  10. XM_054346618.1 → XP_054202593.1  myosin light chain kinase, smooth muscle isoform X14

  11. XM_054346615.1 → XP_054202590.1  myosin light chain kinase, smooth muscle isoform X3

  12. XM_054346622.1 → XP_054202597.1  myosin light chain kinase, smooth muscle isoform X7

  13. XM_054346620.1 → XP_054202595.1  myosin light chain kinase, smooth muscle isoform X6

  14. XM_054346623.1 → XP_054202598.1  myosin light chain kinase, smooth muscle isoform X7

  15. XM_054346628.1 → XP_054202603.1  myosin light chain kinase, smooth muscle isoform X9

  16. XM_054346627.1 → XP_054202602.1  myosin light chain kinase, smooth muscle isoform X11

  17. XM_054346626.1 → XP_054202601.1  myosin light chain kinase, smooth muscle isoform X10

    UniProtKB/TrEMBL
    A0A8I5KTQ1

  18. XM_054346630.1 → XP_054202605.1  myosin light chain kinase, smooth muscle isoform X13

  19. XM_054346629.1 → XP_054202604.1  myosin light chain kinase, smooth muscle isoform X12

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005965.3: Suppressed sequence

    Description
    NM_005965.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_053029.2: Suppressed sequence

    Description
    NM_053029.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  3. NM_053030.2: Suppressed sequence

    Description
    NM_053030.2: This RefSeq was permanently suppressed because there was insufficient support for the transcript and the CDS was partial.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15746.4 GenPept UniProtKB/Swiss-Prot:Q15746

Gene LinkOut

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