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NUBP1 NUBP iron-sulfur cluster assembly factor 1, cytosolic [ Homo sapiens (human) ]

Gene ID: 4682, updated on 27-Nov-2024

Summary

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Official Symbol
NUBP1provided by HGNC
Official Full Name
NUBP iron-sulfur cluster assembly factor 1, cytosolicprovided by HGNC
Primary source
HGNC:HGNC:8041
See related
Ensembl:ENSG00000103274 MIM:600280; AllianceGenome:HGNC:8041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NBP; NBP1; CIAO5; NBP35
Summary
NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in adrenal (RPKM 9.0), heart (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

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See NUBP1 in Genome Data Viewer
Location:
16p13.13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (10743842..10769351)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (10779762..10805269)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (10837699..10863208)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MT-ATP6 pseudogene 24 Neighboring gene MT-CO3 pseudogene 24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10386 Neighboring gene trans-golgi network vesicle protein 23 homolog A Neighboring gene NANOG hESC enhancer GRCh37_chr16:10883659-10884197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10387 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:10932437-10932956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10391 Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:10964767-10965966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10398 Neighboring gene class II major histocompatibility complex transactivator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7195 Neighboring gene Dexi homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning of a human cDNA encoding a putative nucleotide-binding protein related to Escherichia coli MinD. Shahrestanifar M, et al. Gene, 1994 Sep 30. PMID 7926816
  2. Unraveling the mechanism of [4Fe-4S] cluster assembly on the N-terminal cluster binding site of NUBP1. Bargagna B, et al. Protein Sci, 2023 May. PMID 36916754, Free PMC Article
  3. GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic Iron-Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to NUBP1. Camponeschi F, et al. J Am Chem Soc, 2020 Jun 17. PMID 32429669, Free PMC Article
  4. Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis. Stehling O, et al. Mol Cell Biol, 2008 Sep. PMID 18573874, Free PMC Article
  5. The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm. Taniguchi N, et al. J Biol Chem, 2000 Oct 13. PMID 10915798

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unraveling the mechanism of [4Fe-4S] cluster assembly on the N-terminal cluster binding site of NUBP1.
    Title: Unraveling the mechanism of [4Fe-4S] cluster assembly on the N-terminal cluster binding site of NUBP1.
  2. GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic Iron-Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to NUBP1.
    Title: GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic Iron-Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to NUBP1.
  3. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: PTEN identified as important risk factor of chronic obstructive pulmonary disease.
  5. The cytosolic soluble P-loop NTPase termed huNbp35 (also known as Nubp1) was identified as an Fe/S protein, and its role in the maturation of Fe/S proteins in HeLa cells, is defined.
    Title: Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117406, MGC130052, MGC130053

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent FeS chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron-sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome localization IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to cell cortex IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
cytosolic Fe-S cluster assembly factor NUBP1
Names
NBP 1
nucleotide binding protein (e.coli MinD like)
nucleotide binding protein 1 (E.coli MinD like)
nucleotide binding protein 1 (MinD homolog, E. coli)
nucleotide-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278506.2 → NP_001265435.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 2

    See identical proteins and their annotated locations for NP_001265435.1

    Status: VALIDATED

    Source sequence(s)
    AK223204, BC100290, BP225034
    Consensus CDS
    CCDS61839.1
    UniProtKB/Swiss-Prot
    P53384
    Related
    ENSP00000409654.2, ENST00000433392.6
    Conserved Domains (1) summary
    pfam10609
    Location:53 → 292
    ParA; NUBPL iron-transfer P-loop NTPase

  2. NM_001323594.2 → NP_001310523.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC074136

  3. NM_001323595.2 → NP_001310524.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC074136
    Conserved Domains (2) summary
    COG0489
    Location:38 → 273
    Mrp; Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster [Cell cycle control, cell division, chromosome partitioning]
    pfam10609
    Location:53 → 273
    ParA; NUBPL iron-transfer P-loop NTPase

  4. NM_001323596.2 → NP_001310525.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC074136

  5. NM_001323597.1 → NP_001310526.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC074136

  6. NM_002484.4 → NP_002475.2  cytosolic Fe-S cluster assembly factor NUBP1 isoform 1

    See identical proteins and their annotated locations for NP_002475.2

    Status: VALIDATED

    Source sequence(s)
    AK223204, BP225034
    Consensus CDS
    CCDS10543.1
    UniProtKB/Swiss-Prot
    P53384, Q32M30, Q498A9, Q53FS7
    Related
    ENSP00000283027.5, ENST00000283027.10
    Conserved Domains (2) summary
    TIGR01969
    Location:57 → 303
    minD_arch; cell division ATPase MinD, archaeal
    pfam10609
    Location:53 → 303
    ParA; NUBPL iron-transfer P-loop NTPase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    10743842..10769351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434170.1 → XP_047290126.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    10779762..10805269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380401.1 → XP_054236376.1  cytosolic Fe-S cluster assembly factor NUBP1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53384.2 GenPept UniProtKB/Swiss-Prot:P53384

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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