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qsm quasimodo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47065, updated on 4-Jan-2025

Summary

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Official Symbol
qsmprovided by FlyBase
Official Full Name
quasimodoprovided by FlyBase
Primary source
FLYBASE:FBgn0028622
Locus tag
Dmel_CG13432
See related
AllianceGenome:FB:FBgn0028622
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13432; CG13433; Dmel\CG13432; EP2356; EP2587; l(2)05510; L(2)05510; l(2)k009920; lethal (2) 05510; Qsm; QSM
Summary
Involved in locomotor rhythm. Is expressed in several structures, including adult pacemaker neurons; cuboidal/columnar epithelium; gut section; imaginal disc; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See qsm in Genome Data Viewer
Location:
57A5-57A6; 2-91 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20563034..20583591, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16450539..16471096, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene lateral muscles scarcer Neighboring gene Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Neighboring gene antisense RNA:CR44653 Neighboring gene uncharacterized protein Neighboring gene mir-310 stem loop Neighboring gene mir-311 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Null mutations in Drosophila N-acetylglucosaminyltransferase I produce defects in locomotion and a reduced life span. Sarkar M, et al. J Biol Chem, 2006 May 5. PMID 16522637
  2. Mechano-chemical enforcement of tendon apical ECM into nano-filaments during Drosophila flight muscle development. Chu WC, et al. Curr Biol, 2021 Apr 12. PMID 33545042
  3. The opposing chloride cotransporters KCC and NKCC control locomotor activity in constant light and during long days. Eick AK, et al. Curr Biol, 2022 Mar 28. PMID 35303416
  4. Dissecting the daily feeding pattern: Peripheral CLOCK/CYCLE generate the feeding/fasting episodes and neuronal molecular clocks synchronize them. Maruko A, et al. iScience, 2023 Nov 17. PMID 37915609, Free PMC Article
  5. QUASIMODO, a Novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock. Chen KF, et al. Curr Biol, 2011 May 10. PMID 21530261

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Qsm affects both daily and acute light effects in large ventral lateral neurons.
    Title: Quasimodo mediates daily and acute light effects on Drosophila clock neuron excitability.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
quasimodo
Names
CG13432-PA
CG13432-PB
lethal (2) 05510
qsm-PA
qsm-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20563034..20583591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299708.1 → NP_001286637.1  quasimodo, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286637.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3W4
    Conserved Domains (2) summary
    smart00241
    Location:30 → 298
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:200 → 300
    Zona_pellucida; Zona pellucida-like domain

  2. NM_143792.3 → NP_652049.1  quasimodo, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652049.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3W4
    Related
    FBpp0085570
    Conserved Domains (2) summary
    smart00241
    Location:30 → 298
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:200 → 300
    Zona_pellucida; Zona pellucida-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K3W4 Q7K3W4

Gene LinkOut

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